EphA7 isoforms differentially regulate cortical dendrite development.
PLoS ONE, 2020 The shape of a neuron facilitates its functionality within neural circuits. Dendrites integrate incoming signals from axons, receiving excitatory input onto small protrusions called dendritic spines.
Carrie E Leonard +4 more
doaj +1 more source
Three-dimensional spatial modeling of spines along dendritic networks in human cortical pyramidal neurons. [PDF]
PLoS ONE, 2017 We modeled spine distribution along the dendritic networks of pyramidal neurons in both basal and apical dendrites. To do this, we applied network spatial analysis because spines can only lie on the dendritic shaft.
Laura Anton-Sanchez +5 more
doaj +1 more source
Altered dendritic spine function and integration in a mouse model of fragile X syndrome
Nature Communications, 2018 Cellular and circuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disorder models. However, the cellular and synaptic bases of this hyperexcitability have proved elusive.
Sam A. Booker +7 more
semanticscholar +1 more source
Dendritic spine alterations in schizophrenia [PDF]
Neuroscience Letters, 2015 Schizophrenia is a chronic illness affecting approximately 0.5-1% of the world's population. The etiology of schizophrenia is complex, including multiple genes, and contributing environmental effects that adversely impact neurodevelopment. Nevertheless, a final common result, present in many subjects with schizophrenia, is impairment of pyramidal ...
Caitlin E. Moyer +2 more
semanticscholar +3 more sources
Image informatics strategies for deciphering neuronal network connectivity [PDF]
, 2016 Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani +99 more
core +2 more sources
Spinal cord motor neuron plasticity accompanies second‐degree burn injury and chronic pain
Physiological Reports, 2019 Burn injuries and associated complications present a major public health challenge. Many burn patients develop clinically intractable complications, including pain and other sensory disorders. Recent evidence has shown that dendritic spine neuropathology
Siraj Patwa +7 more
doaj +1 more source
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Whether learning-induced changes in neuronal circuits are inhibited or erased during the process of unlearning remains unclear. In this study, we examined the impact of auditory-cued fear conditioning and extinction on the remodeling of ...
C. S. Lai, Avital Adler, W. Gan
semanticscholar +1 more source
Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
Scientific Reports, 2020 Stress alters the structure and function of brain reward circuitry and is an important risk factor for developing depression. In the nucleus accumbens (NAc), structural and physiological plasticity of medium spiny neurons (MSNs) have been linked to ...
Megan E. Fox +3 more
doaj +1 more source
Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism. [PDF]
PLoS ONE, 2014 General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction.
Jimcy Platholi +3 more
doaj +1 more source