Results 81 to 90 of about 87,585 (230)
PLoS Biology, 2023 Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain that control synaptic activity and plasticity.
Hsiao-Tang Hu +6 more
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Rapid, learning-induced inhibitory synaptogenesis in murine barrel field [PDF]
, 2010 The structure of neurons changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape, and dimensions of dendritic spines together with their synapses. However, precise data on these changes
Cybulska-Klosowicz, A +6 more
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Small, smaller… dendritic spine [PDF]
The EMBO Journal, 2014 Spines are highly motile protrusions emerging from the dendritic shafts of neurons. The dynamics of these post‐synaptic structures are ruled by actin filament turnover. However, our understanding of the mechanisms of actin polymerization in dendritic spines is quite ambiguous.
Pietro Pilo Boyl, Walter Witke
openaire +3 more sources
Network Plasticity as Bayesian Inference [PDF]
, 2015 General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing.
Habenschuss, Stefan +3 more
core +6 more sources
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
Neurobiology of Disease, 2009 Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer's disease and mouse models ...
Tara L. Spires-Jones +7 more
doaj +1 more source
A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]
, 2018 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H +14 more
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Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]
, 2016 Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia +5 more
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Microtubules in Dendritic Spine Development [PDF]
The Journal of Neuroscience, 2008 It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation.
Bonnie L. Firestein +3 more
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Biological Research, 2023 Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu +10 more
doaj +1 more source
The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
core +2 more sources