Results 111 to 120 of about 553,059 (371)

A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation

Advanced Functional Materials, EarlyView.
This study shows a biomimetic silica microcapsule (SMC) fabrication method under mild conditions for making artificial antigen‐presenting cells (aAPCs). Inspired by marine biomineralization, peptide‐mediated biosilicification enables silica shell formation on emulsion templates. The resulting SMCs possess a core–shell structure, controlled fluorescence
Fei Hou, Supun Ranaweera, Xiangke Li, Ruirui Qiao, Yue Hui, Chun‐Xia Zhao   +5 more
wiley   +1 more source

Electrical behaviour of dendritic spines as revealed by voltage imaging

Nature Communications, 2015
Thousands of dendritic spines on individual neurons process information and mediate plasticity by generating electrical input signals using a sophisticated assembly of transmitter receptors and voltage-sensitive ion channel molecules.
Marko Popovic, N. Carnevale, B. Rózsa, D. Zecevic   +3 more
semanticscholar   +1 more source

Small, smaller… dendritic spine [PDF]

The EMBO Journal, 2014
Spines are highly motile protrusions emerging from the dendritic shafts of neurons. The dynamics of these post‐synaptic structures are ruled by actin filament turnover. However, our understanding of the mechanisms of actin polymerization in dendritic spines is quite ambiguous.
Pietro Pilo Boyl, Walter Witke
openaire   +3 more sources

Topological Insulator Layered Bi2Te3 Based 3D‐Printed Nanocarbon Electrode for Rechargeable Aqueous Ammonium‐Ion Battery

Advanced Functional Materials, EarlyView.
In this work, Bi2Te3 is integrated into a 3D‐printed nanocarbon electrode for NH4+ storage. A rocking‐chair battery with CuHCF as the cathode delivers a high energy density of 134.8 Wh kg−1 and a power density of 1800 W kg−1. The design allows easy recovery of carbon additives, promoting sustainability and recyclability in next‐generation aqueous ...
Sunny Nandi, Martin Pumera
wiley   +1 more source

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX

Journal of Cell Biology, 2015
In neurons, KCC2 controls glutamatergic synaptogenesis and regulates actin polymerization in dendritic spines by binding β-PIXb and attenuating its GEF activity toward small GTPase Rac1.
O. Llano, Sergey Smirnov, Shetal Soni, A. Golubtsov, I. Guillemin, Pirta Hotulainen, I. Medina, H. Nothwang, C. Rivera, Anastasia Ludwig   +9 more
semanticscholar   +1 more source

Fluorophobic Effect Enables Selective Detection of PFAS in Water with Electrolyte‐Gated Organic Transistors

Advanced Functional Materials, EarlyView.
PerFluoroAlkyl Substances (PFAS) are responsible of major and persistent environmental pollution worldwide. This work demonstrates an ultra‐sensitive sensor for PFAS based on an organic transistor whose gate is functionalized with a binary self‐assembled monolayer containing a perfluorinated molecule.
Rian Zanotti, Marcello Berto, Matteo Sensi, Alessandro Paradisi, Eleonora Veronese, Lucia Pasquato, Carlo Augusto Bortolotti, Pierangelo Metrangolo, Fabio Biscarini   +8 more
wiley   +1 more source

Microtubules in Dendritic Spine Development [PDF]

The Journal of Neuroscience, 2008
It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation.
Bonnie L. Firestein, Jiaping Gu, James Q. Zheng, James Q. Zheng   +3 more
openaire   +3 more sources

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

Nature Communications, 2020
In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez, Shuting Yin, Christian Schulze, John A. Hammer, Wolfgang Wagner, Thomas G. Oertner   +5 more
doaj   +1 more source

Actin reorganization in hippocampal neurons may play a role in early learning and memory impairment after propofol anesthesia in rats

Journal of International Medical Research, 2023
Objectives To observe changes in actin and dendritic spines in the hippocampus after propofol anesthesia, and to evaluate the role of these changes in subsequent learning impairment in both young (3-month-old) and aged (20-month-old) male rats.
Xuena Zhang, Jie Li
doaj   +1 more source