Results 251 to 260 of about 43,830 (285)

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

PI3K couples long-term synaptic potentiation with cofilin recruitment and actin polymerization in dendritic spines via its regulatory subunit p85α. [PDF]

Cell Mol Life Sci
López-García S, López-Merino E, Fernández-Rodrigo A, Zamorano-González P, Gutiérrez-Eisman S, Jiménez-Sánchez R, Esteban JA.   +6 more
europepmc   +1 more source

Expediting Desolvation–Diffusion Kinetics by Self‐Cascade Catalysis for Durable Low‐Temperature Zinc Metal Batteries

Angewandte Chemie, EarlyView.
A novel self‐cascade catalytic strategy is proposed by designing an atomically dispersed Bi on deficient LaMnO3.15 perovskite (SABi/U‐LMO), serving as a promoter on subsequently lateral deposition of Zn enabled by interfacial electric field regulation.
Xiaomin Cheng, Wenbin Wang, Zhiyong Tang, Yongzheng Zhang, Bixian Chen, Jing Zhang, Fangmin Ye, Jing Dong, Hao Li, Jiqiang Jia, Qingbo Xiao, Hongzhen Lin, Jian Wang   +12 more
wiley   +1 more source

Restoration of norepinephrine release, cognitive performance, and dendritic spines by amphetamine in aged rat brain. [PDF]

Aging Cell
Scognamiglio S, Aljohani YM, Olson TT, Forcelli PA, Dezfuli G, Kellar KJ.   +5 more
europepmc   +1 more source

JNK activity modulates postsynaptic scaffold protein SAP102 and kainate receptor dynamics in dendritic spines. [PDF]

J Biol Chem
Kunde SA, Schmerl B, von Sivers J, Ahmadyar E, Gupta T, Rademacher N, Zieger HL, Shoichet SA.   +7 more
europepmc   +1 more source

Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus. [PDF]

Neurosci Bull
Deng L, Song SY, Zhao WM, Meng XW, Liu H, Zheng Q, Peng K, Ji FH.   +7 more
europepmc   +1 more source

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Dendritic Spine Dynamics

Annual Review of Physiology, 2009
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
D Harshad, Bhatt, Shengxiang, Zhang, Wen-Biao, Gan   +2 more
openaire   +2 more sources

Microtubules, dendritic spines and spine apparatuses

Cell and Tissue Research, 1980
Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate ...
L E, Westrum, D H, Jones, E G, Gray, J, Barron   +3 more
openaire   +2 more sources

Dendritic Spines and Pain Memory

The Neuroscientist, 2022
Neuropathic pain is a debilitating form of pain arising from injury or disease of the nervous system that affects millions of people worldwide. Despite its prevalence, the underlying mechanisms of neuropathic pain are still not fully understood. Dendritic spines are small protrusions on the surface of neurons that play an important role in synaptic ...
Curtis A. Benson, Jared F. King, Marike L. Reimer, Sierra D. Kauer, Stephen G. Waxman, Andrew M. Tan   +5 more
openaire   +2 more sources