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Dengue, caused by infection of any of four dengue virus serotypes (DENV-1 to DENV-4), is a mosquito-borne disease of major public health concern associated with significant morbidity, mortality, and economic cost, particularly in developing countries. Dengue incidence has increased 30-fold in the last 50 years and over 50% of the world’s population, in
Harapan Harapan+3 more
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Dengue, caused by four closely related viruses, is a growing global public health concern, with outbreaks capable of overwhelming health-care systems and disrupting economies. Dengue is endemic in more than 100 countries across tropical and subtropical regions worldwide, and the expanding range of the mosquito vector, affected in part by climate change,
Billick MJ, Bogoch II.
europepmc +6 more sources
Dengue and Dengue Hemorrhagic Fever [PDF]
SUMMARYDengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions.
Edward B. Hayes, Duane J. Gubler
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Is new dengue vaccine efficacy data a relief or cause for concern?
Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensive countermeasure strategy. Despite decades of attempts, the world has a single dengue vaccine licensed in numerous countries, but ...
Stephen J. Thomas
semanticscholar +1 more source
Efficacy of Wolbachia-infected mosquito deployments for the control of dengue
Background: Aedes aegypti mosquitoes infected with Wolbachia pipientis (wMel strain) have reduced potential to transmit dengue viruses. Methods: We conducted a cluster randomised trial of deployments of wMel-infected Ae.
A. Utarini+23 more
semanticscholar +1 more source
Dengue and dengue haemorrhagic fever [PDF]
The incidence and geographical distribution of dengue have greatly increased in recent years. Dengue is an acute mosquito-transmitted viral disease characterised by fever, headache, muscle and joint pains, rash, nausea, and vomiting. Some infections result in dengue haemorrhagic fever (DHF), a syndrome that in its most severe form can threaten the ...
Rigau-Pérez, J+5 more
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Dengue infection: Global importance, immunopathology and management.
Dengue is an arboviral infection that is hyperendemic in tropical and subtropical climates. Clinical manifestations of dengue can range from asymptomatic infection to severe infection with multi-organ failure.
S. Kularatne, Chamara Dalugama
semanticscholar +1 more source
Dengue is a vector-borne viral infection that endangers an estimated 2.5 billion people. Disease caused by dengue ranges from a relatively minor febrile illness to a life-threatening condition characterized by extensive capillary leak. A greater understanding of dengue has the potential to improve both the clinical management of individual cases and ...
Whitehorn, J, Farrar, J
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Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a public health challenge with an economic burden that is currently unmet by licensed vaccines, specific therapeutic agents, or efficient vectorcontrol strategies.
Simmons, CP+3 more
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Dengue Virus: Epidemiology, Biology and Disease Aetiology.
Dengue is a vector-borne viral disease, caused by the Flavivirus, Dengue virus (DENV). About 400 million cases and 22000 deaths occur due to dengue throughout the world each year.
Sudipta Roy, S. Bhattacharjee
semanticscholar +1 more source