Results 41 to 50 of about 230,109 (316)

Drug repurposing approach against chikungunya virus: an in vitro and in silico study

Frontiers in Cellular and Infection Microbiology, 2023
The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes. There are no licenced antivirals or vaccines for treatment or prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses of therapeutics to
Bhagyashri Kasabe, Gunwant Ahire, Poonam Patil, Madhura Punekar, Kusuma Sai Davuluri, Mahadeo Kakade, Kalichamy Alagarasu, Deepti Parashar, Sarah Cherian   +8 more
doaj   +1 more source

Zika virus infection enhances future risk of severe dengue disease

Science, 2020
Double whammy Dengue and Zika virus epidemics have been lapping each other around the globe. These are closely related mosquito-borne viruses with about 40% homology within the envelope protein.
L. Katzelnick, César Narvaez, Sonia Arguello, Brenda Lopez Mercado, Damaris Collado, Oscarlett Ampie, Douglas Elizondo, Tatiana Miranda, Fausto Bustos Carillo, J. Mercado, Krista Latta, Amy J Schiller, Bruno Segovia-Chumbez, S. Ojeda, N. Sanchez, M. Plazaola, J. Coloma, M. Halloran, L. Premkumar, A. Gordon, Federico Narvaez, A. D. de Silva, G. Kuan, Á. Balmaseda, E. Harris   +24 more
semanticscholar   +1 more source

Antibody fucosylation predicts disease severity in secondary dengue infection

Science, 2021
IgG fucosylation predicts dengue severity Secondary infections with dengue virus (DENV) can produce life-threatening symptoms, including thrombocytopenia and hemorrhagic disease, when preexisting DENV-reactive immunoglobulin G1 (IgG1) antibodies promote ...
S. Bournazos, Hoa Thi My Vo, V. Duong, H. Auerswald, S. Ly, A. Sakuntabhai, P. Dussart, T. Cantaert, J. Ravetch   +8 more
semanticscholar   +1 more source

Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases

Brazilian Journal of Infectious Diseases
INTRODUCTION: Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis.
Luiz José de Souza, José Galvão Alves, Rita Maria Ribeiro Nogueira, Carlos Gicovate Neto, Diogo Assed Bastos, Edno Wallace da Silva Siqueira, João Tadeu Damian Souto Filho, Thiago de Abreu Cezário, Carlos Eduardo Soares, Rodrigo da Costa Carneiro   +9 more
doaj   +1 more source

Comparison of clinical and laboratory characteristics between children and adults with dengue

Brazilian Journal of Infectious Diseases
Over the past several years, the epidemiological profile of dengue has been changing progressively and is currently characterized by an increase in the number of cases in children under 15 years of age.
Luiz José de Souza, Laís Bastos Pessanha, Laura Carvalho Mansur, Luiza Assed de Souza, Mariana Barbosa Tâmega Ribeiro, Monique do Vale da Silveira, João Tadeu Damian Souto Filho   +6 more
doaj   +1 more source

Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children

BMC Research Notes, 2019
Objective Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka.
Mihira Manamperi, Bernard Deepal Wanniarachchi Jayamanne, Thilini Somaratne, Natasha Perera, LakKumar Fernando   +4 more
doaj   +1 more source

Mapping global variation in dengue transmission intensity

Science Translational Medicine, 2020
A downloadable high-resolution map of global dengue transmission intensity helps predict the potential impact of control strategies. At last, an atlas of dengue spread Transmitted by Aedes mosquitos worldwide, dengue virus causes flu-like symptoms and ...
L. Cattarino, I. Rodríguez-Barraquer, N. Imai, D. Cummings, N. Ferguson   +4 more
semanticscholar   +1 more source

Integrated vector control of Aedes aegypti mosquitoes around target houses

Parasites & Vectors, 2018
Background The developing fetuses of pregnant women are at high risk of developing serious birth defects following Zika virus infections. We applied an Integrated Vector Control (IVC) approach using source reduction, larviciding, and mass trapping with ...
Roberto Barrera, Manuel Amador, Jorge Munoz, Veronica Acevedo   +3 more
doaj   +1 more source

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2

Viruses, 2022
The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical regions of the world emphasizes the need to identify effective therapeutic drugs against the disease.
Madhura Punekar, Bhagyashri Kasabe, Poonam Patil, Mahadeo B. Kakade, Deepti Parashar, Kalichamy Alagarasu, Sarah Cherian   +6 more
doaj   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source