Results 41 to 50 of about 152,116 (307)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018

International Journal of Infectious Diseases, 2021
: Objectives: A retrospective study was undertaken to investigate the circulating dengue virus (DENV) serotypes and genotypes in India in 2018. Methods: In total, 4963 samples referred to virus research diagnostic laboratories (n=21), the Indian Council
K. Alagarasu, J.A. Patil, M.B. Kakade, A.M. More, B. Yogesh, P. Newase, S.M. Jadhav, D. Parashar, H. Kaur, N. Gupta, N. Vijay, J. Narayan, P.S. Shah, Dr Ajanta Sharma, Dr Amita Jain, Dr Anudita Bhargava, Dr B. Anukumar, Dr Ashok M, Dr Bharti Malhotra, Dr B.J. Borkakoty, Dr Debasis Biswas, Dr SC Jaryal, Dr Kanwardeep Singh Dhingra, Dr K. Kaveri, Dr P.K. Khatri, Dr Manoj Kumar, Dr K. Nagamani, Dr Rahul Dhodapkar, Dr Rupinder Bakshi, Dr Paramjeet S. Gill, Dr Sanghamitra Pati, Dr Shanta Dutta, Dr Shantala G, Dr Usha Kalawat, Dr Disha A. Patel, Dr P. Vijayachari   +35 more
doaj   +1 more source

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

Advanced Intelligent Discovery, EarlyView.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki, Bassam Bachour Junior, Marcelo Mulato, José Ilton de Oliveira Filho   +3 more
wiley   +1 more source

Understanding dengue solution and larval indices surveillance system among village health volunteers in high- and low-risk dengue villages in southern Thailand

One Health, 2022
Background: Successful dengue solutions require community collaboration between agencies engaged in human health, vector control and the environment.
Orratai Nontapet, Sarunya Maneerattanasak, Jiraporn Jaroenpool, Atchara Phumee, Wirut Krachai, Pawinee Napet, Md. Siddikur Rahman, Charuai Suwanbamrung   +7 more
doaj   +1 more source

Dengue Disease [PDF]

AAOHN Journal, 2010
Dengue is currently the world's most rapidly spreading mosquito-borne illness.
openaire   +2 more sources

Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability

Animal Models and Experimental Medicine, EarlyView.
Optimized dengue fever animal model: IFNAR−/− BALB/c mice with intraperitoneal injection. Background screening: Between IFNAR−/− (BALB/c, C57BL/6) and AG129 mice, IFNAR−/−BALB/c exhibited the most severe symptoms: (1) highest weight loss and clinical scores; (2) peak viremia (5.44 log10 RNA copies/mL, day 4); (3) significant organ damage (liver/brain ...
Dan Liao, Ming Zhong, Wenjiang Zheng, Zhendong Guo, Ye Zhou, Qiuhong Li, Lijuan Qiu, Liangwen Yu, Haishan Long, Geng Li   +9 more
wiley   +1 more source

INHIBITORY ACTIVITY OF COBALT(II)–MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2

Indonesian Journal of Tropical and Infectious Disease, 2017
Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue.
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati Setyawati, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Shuhai Ueda, Tomohiro Kotaki, Sri Sumarsih, Puspa Wardhani, Sri Subekti Bendryman, Aryati Aryati, Soegeng Soegijanto, Masanori Kameoka   +12 more
doaj   +1 more source

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

Dengue conundrums

International Journal of Antimicrobial Agents, 2010
Dengue virus is the most common arboviral infection of humans in the tropical and subtropical regions of the world. This review briefly describes some of the challenges it presents. Dengue is an emerging disease; it is increasing in geographical distribution and severity, despite being significantly underreported.
openaire   +2 more sources

A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity [PDF]

, 2022
Yaning Gao, Wanbo Tai, Xinyi Wang, Shibo Jiang, Asim K. Debnath, Lanying Du, Shizhong Chen   +6 more
openalex   +1 more source