Results 81 to 90 of about 6,470,188 (388)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Visualizing the large-$Z$ scaling of the kinetic energy density of atoms

, 2016
The scaling of neutral atoms to large $Z$, combining periodicity with a gradual trend to homogeneity, is a fundamental probe of density functional theory, one that has driven recent advances in understanding both the kinetic and exchange-correlation ...
Cancio, Antonio C., Redd, Jeremy J.
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Evaluación de las técnicas de capacitación espermática y su efecto en la fragmentación del ADN Assesment of sperm capacitation techniques and their effect on DNA fragmentation

Revista Colombiana de Obstetricia y Ginecología, 2012
Objetivo: evaluar el efecto de las técnicas de capacitación espermática en la fragmentación del ADN. Materiales y métodos: estudio experimental en el cual se describió el efecto de las técnicas de capacitación espermática swim up y gradientes de densidad
Luisa Calderón-Mendoza, Carlos Vivas-Ramírez, Lina De los Reyes   +2 more
doaj  

Receptor Density-Dependent Motility of Influenza Virus Particles on Surface Gradients [PDF]

, 2023
P. H. Erik Hamming, Nico J. Overeem, Kevin Diestelhorst, Tren Fiers, Malte Tieke, Gaël M. Vos, Geert‐Jan Boons, Erhard van der Vries, Stephan Block, Jurriaan Huskens   +9 more
openalex   +1 more source

Turbulence without pressure in d dimensions

, 1999
The randomly driven Navier-Stokes equation without pressure in d-dimensional space is considered as a model of strong turbulence in a compressible fluid. We derive a closed equation for the velocity-gradient probability density function.
A. Chekhlov, A. Polyakov, E. Balkovsky, E. Ivashkevich, J. Zinn-Justin, J.-P. Bouchaud, J.-P. Bouchaud, M. L. Mehta, S. A. Boldyrev, S. Boldyrev, S. Boldyrev, T. Gotoh, T. Gotoh, V. Gurarie, V. Yakhot, V. Yakhot, W. E   +16 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Mechanism investigation and models evaluation of gas transport in dual-porosity coal seam

Meitan kexue jishu
Methane is an unconventional natural gas in coal seams. Coalbed methane (CBM) migration behavior constitutes a core issue in coalbed methane extraction. However, there is no consensus on the gas migration mechanism of dual-porosity coal seams.
Wei LIU, Dongyang HAN, Hao XU, Yujun ZHOU, Tiannan LI   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

E05 Mutation-related apparent myelin, not axon density, drives white matter pathology in premanifest huntington’s disease: evidence from in vivo ultra-strong gradient MRI [PDF]

, 2021
Chiara Casella, Maxime Chamberland, Pedro Luque Laguna, Greg D. Parker, Anne Rosser, Elizabeth Coulthard, Hugh Rickards, Derek K. Jones, Claudia Metzler‐Baddeley   +8 more
openalex   +1 more source