Results 111 to 120 of about 5,484,719 (297)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

[Stem cells of dental pulp].

Comptes rendus biologies, 2007
Any clinician dreams to obtain the regeneration of the destroyed organ for his patient. In the human being, the regeneration of complex structures is not possible, except the liver and the bone marrow, which can be regenerated because of the presence of adult stem cells in these tissues.
Emmanuelle, Renard, Séréna, Lopez-Cazaux, Jérome, Guicheux, Pierre, Weiss, Olivier, Laboux, Brigitte, Alliot-Licht   +5 more
openaire   +1 more source

Quantitative collagen and proteoglycan imaging reveal organic layering, gradients and regional texture in young mature dental cementum

VIEW, EarlyView.
Cementum, the mineralized tissue covering all mammalian tooth roots, helps maintain tooth stability, but its internal organization is still poorly understood. In this study, we combine quantitative histologial methods to map the regional distributions of collagen fibers and proteoglycan‐rich matrix layers in porcine cementum.
Jie Zhen, Yuyang Mao, Hamza Elfarraj, Paul Zaslansky   +3 more
wiley   +1 more source

What Outcomes Matter in Vital Pulp Therapy? Current Concepts and Challenges

Australian Dental Journal, EarlyView.
ABSTRACT Vital pulp therapy (VPT) has re‐emerged as a practical and biologically sound alternative for managing deep caries and carious pulp exposures. Although its clinical use is now widespread, the outcomes used to judge the success of VPT remain inconsistent and often difficult to compare across studies.
Philip Yuan‐Ho Chien, Sepanta Hosseinpour, Richard Huynh, Graham Xuanwei Wong, Christine Inge Peters, Ove Andreas Peters   +5 more
wiley   +1 more source

Biocompatibility With Osteogenic Potential of Premixed Bioceramic Cements for Use in Apical Surgery

Australian Endodontic Journal, EarlyView.
ABSTRACT This study investigated the biocompatibility and osteogenic potential of premixed bioceramic cements (PBCs)—CeraPutty, EndoCEM MTA Premixed, Well‐Root PT, and One‐Fil PT Injectable—as alternatives to mineral trioxide aggregate for retrograde filling in endodontic microsurgery.
Yesol Kim, Jae‐Hoon Kim, Unni Krishnan, Hyeon‐Cheol Kim, Minju Song, Sang Won Kwak   +5 more
wiley   +1 more source

Sodium Diclofenac‐Loaded Drug Delivery Microspheres: Impact on Calcium Hydroxide Paste Properties and Biological Response

Australian Endodontic Journal, EarlyView.
ABSTRACT This study evaluated whether the incorporation of sodium diclofenac‐loaded microspheres into a calcium hydroxide paste enhances antibiofilm activity while maintaining physicochemical properties and biocompatibility. Calcium hydroxide paste, calcium hydroxide combined with sodium diclofenac, and calcium hydroxide containing sodium diclofenac ...
João Vitor Oliveira de Amorim, Murilo Priori Alcalde, Leonardo Cabau, Rodrigo Ricci Vivan, Paulo Henrique Weckwerth, Marco Antonio Hungaro Duarte, Guilherme Ferreira da Silva   +6 more
wiley   +1 more source

A modified efficient method for dental pulp stem cell isolation

Dental Research Journal, 2014
Background: Dental pulp stem cells can be used in regenerative endodontic therapy. The aim of this study was to introduce an efficient method for dental pulp stem cells isolation.
Maryam Raoof, Mohammad Mehdi Yaghoobi, Ali Derakhshani, Ali Mohammadi Kamal-abadi, Behnam Ebrahimi, Mehdi Abbasnejad, Noushin Shokouhinejad   +6 more
doaj  

Dental Pulp Stem Cells: Advances to Applications.

Stem cells and cloning : advances and applications, 2020
Dental pulp stem cells (DPSCs) have a high capacity for differentiation and the ability to regenerate a dentin/pulp-like complex. Numerous studies have provided evidence of DPSCs' differentiation capacity, such as in neurogenesis, adipogenesis, osteogenesis, chondrogenesis, angiogenesis, and dentinogenesis.
openaire   +3 more sources

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source