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Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha +12 more
wiley +1 more source
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang +8 more
wiley +1 more source
Human Atlas of Tooth Decay Progression This cover presents a high‐resolution volumetric image of the vasculature within a healthy human dental pulp. This 3D reconstruction reveals the remarkable complexity and beauty of the pulp's microvascular tree, captured through advanced clearing and imaging approaches. The result is an extraordinary visualization
Hoang Thai Ha +12 more
wiley +1 more source
Hierarchical Self‐Assembled Nanoparticles for Efficient and Eco‐Friendly Herbicide Delivery
Hierarchical host–guest and electrostatic self‐assembly of Diuron/SBE‐β‐CD@CSH for enhanced herbicide efficacy and environmentally safe delivery. ABSTRACT Herbicides are indispensable for safeguarding global crop production, yet their effectiveness is often undermined by extensive environmental losses during application.
Yuntian Xiao +6 more
wiley +1 more source
ABSTRACT Objectives Antifungal drug resistance poses a major challenge in treating oral Candida infections. This study aimed to evaluate the antifungal activity of Honokiol, alone and combined with Fluconazole, against oral Candida isolates, and to investigate its mechanism of action via ergosterol biosynthesis inhibition and cell wall disruption ...
Maribasappa Karched +2 more
wiley +1 more source
ABSTRACT Purpose Guided endodontics allows precise access in challenging cases such as calcified canals; however, drilling can generate temperature increases that risk damaging periradicular tissues. This study aimed to evaluate the influence of different sleeve materials—zirconia, cobalt‐chromium (CoCr), and titanium—on temperature changes during ...
Anna Muryani +5 more
wiley +1 more source
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Dental Pulp Stem Cell Migration
Journal of Endodontics, 2010The purpose of this in vitro study was to investigate the migration of dental pulp stem cells (DPSCs) in response to chemotactants and extracellular matrix proteins (EMPs). This DPSC signaling information is needed to help understand tooth regeneration after injury and to develop some future regenerative endodontic therapies.DPSCs were released by ...
Cameron, Howard +2 more
openaire +2 more sources
2006
Postnatal stem cells have been isolated from a variety of tissues. These stem cells are thought to possess great therapeutic potential for repairing damaged and/or defective tissues. Clinically, hematopoietic stem cells have been successfully used for decades in the treatment of various diseases and disorders.
Liu, H., Gronthos, S., Shi, S.
openaire +3 more sources
Postnatal stem cells have been isolated from a variety of tissues. These stem cells are thought to possess great therapeutic potential for repairing damaged and/or defective tissues. Clinically, hematopoietic stem cells have been successfully used for decades in the treatment of various diseases and disorders.
Liu, H., Gronthos, S., Shi, S.
openaire +3 more sources
Human dental pulp stem cells and hormesis
Ageing Research Reviews, 2022This paper represents the first assessment of hormetic dose responses by human dental pulp stem cells (hDPSCs) with particular emphasis on cell renewal (proliferation) and differentiation. Hormetic dose responses were commonly reported in this model, encompassing a broad range of chemicals, including principally pharmaceuticals (e.g., metformin and ...
Calabrese, Edward J +4 more
openaire +3 more sources
Primary Culture of Dental Pulp Stem Cells
Journal of Visualized Experiments, 2023The human dental pulp represents a promising multipotent stem cell reservoir with pre-eminent regenerative competence that can be harvested from an extracted tooth. The neural crest-derived ecto-mesenchymal origin of dental pulp stem cells (DPSCs) bestows a high degree of plasticity that owes to its multifaceted benefits in tissue repair and ...
Ajay, Kumar +4 more
openaire +2 more sources

