Results 131 to 140 of about 139,984 (307)

Moderate effect of early-life experience on dentate gyrus function [PDF]

, 2022
Pacifique Rukundo, Ting Feng, Vincent Pham, Simon Pieraut   +3 more
openalex   +1 more source

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Cognitive Decline by Restoring Senescent Microglial Function via NF‐κB‐SREBP1 Pathway Inhibition

Aging Cell, EarlyView.
Human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs) ameliorate age‐related cognitive decline by targeting senescent microglia. They attenuate microglial senescence, reduce LD accumulation, and inhibit the NF‐κB‐SREBP1 signaling pathway, ultimately mitigating neuroinflammation and neuronal damage.
Aihong Liang, Li Zhang, Jing Peng, Yanan Li, Yunduo Zhou, Chao Yang, Jie Wang, Yizhong Yan, Hua Mei, Jun Zhu, Siqi Wang, Na Xiao, Yu Zhou, Lamei Cheng   +13 more
wiley   +1 more source

Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy

Neurobiology of Disease
Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ...
Wenxi Yu, Sophie F. Hill, Limei Zhu, Yiannos Demetriou, Faith Reger, Joanna Mattis, Miriam H. Meisler   +6 more
doaj   +1 more source

Adult neurogenesis modifies excitability of the dentate gyrus [PDF]

, 2013
Taruna Ikrar, Nannan Guo, Kaiwen He, B Antoine, Sally Levinson, Alexis S. Hill, Hey‐Kyoung Lee, René Hen, Xiangmin Xu, Amar Sahay   +9 more
openalex   +1 more source

Autophagy is a cell-intrinsic driver of neural stem cell quiescence in hippocampal dentate gyrus development [PDF]

, 2023
Isabel Calatayud-Baselga, L. Casares-Crespo, Carmina Franch-Ibáñez, José Guijarro-Nuez, Pascual Sanz, Helena Mira   +5 more
openalex   +1 more source

Age‐Related Alterations in Hippocampal Microstructure Quantified Using High‐Gradient Diffusion MRI (dMRI) in an Unfolded Hippocampal Space

Aging Cell, EarlyView.
Using high‐gradient diffusion MRI with the SANDI model and HippUnfold for fine‐scale analysis, we detected localized hippocampal aging changes beyond volumetric/thickness reductions. Subiculum and dentate gyrus exhibit significantly reduced soma density/size and increased extracellular space, highlighting subtle microstructural alterations critical for
Yixin Ma, Hansol Lee, Kwok‐Shing Chan, Laleh Eskandarian, Kyla Gaudet, Qiyuan Tian, Aneri Bhatt, Julianna Gerold, Andrew W. Russo, David H. Salat, Eric C. Klawiter, Susie Y. Huang, Hong‐Hsi Lee   +12 more
wiley   +1 more source

A role for hilar cells in pattern separation in the dentate gyrus: A computational approach

, 2008
Catherine E. Myers, Helen E. Scharfman
openalex   +1 more source

Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes [PDF]

, 2019
Iaroslav Savtchouk, Maria Amalia Di Castro, Rugina Ali, Hiltrud Stubbe, Rafael Luján, Andrea Volterra   +5 more
openalex   +1 more source

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source