Results 151 to 160 of about 72,047 (256)

Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus

, 1995
The effects of afferent input and N-methyl-D-aspartate (NMDA) receptor activation on neurogenesis were examined in an intact system, the rat dentate gyrus, where neurons are naturally born in the adult.
HA Cameron, BS McEwen, E Gould
core   +1 more source

The dentate gyrus in depression: directions for future research [PDF]

Molecular Psychiatry, 2020
Jasper O. Nuninga, René C. W. Mandl, Iris E. C. Sommer   +2 more
openaire   +2 more sources

Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort

Brain Pathology, EarlyView.
Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran, Iban Aldecoa, Arlène Sindikubwabo, Núria Vidal, Rafael Blesa, Mercè Martínez‐Corral, Carlos Nos, Verónica Santiago, Andrea González, Álex Iranzo, Christopher J. Nowinski, Ann C. McKee, Raquel Sánchez Valle, Laura Molina‐Porcel   +13 more
wiley   +1 more source

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in a mouse model of Alzheimer’s disease

Neural Regeneration Research
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease. Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.
Mackenzie M. Spicer, Jianqi Yang, Daniel Fu, Alison N. DeVore, Marisol Lauffer, Nilufer S. Atasoy, Deniz Atasoy, Rory A. Fisher   +7 more
doaj   +1 more source

Amygdala vulnerability in Pick disease with discrete frontotemporal dementia syndromes

Brain Pathology, EarlyView.
Clinicopathological characterization of the amygdala in FTLD‐tau. Amygdala vulnerability in FTLD‐tauopathies is defined by elevated neuroinflammation and tau in 3R versus 4R subtypes, and greater neuroinflammation in bvFTD versus PPA. In Pick disease, bvFTD and PPA converge neuropsychiatrically over time, and intracellular tau correlates with increased
Rachel Keszycki, Allegra Kawles, Grace Minogue, Antonia Zouridakis, Alyssa Macomber, Caroline Nelson, Qinwen Mao, Rudolph J. Castellani, Pouya Jamshidi, Nathan Gill, Sandra Weintraub, M.‐Marsel Mesulam, Changiz Geula, Tamar Gefen   +13 more
wiley   +1 more source

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus

, 2016
Within the adult mammalian brain, neurogenesis persists within two main discrete locations, the subventricular zone lining the lateral ventricles, and the hippocampal dentate gyrus.
Dixon, Chantelle, Wood, Stephen A., Burne, Thomas HJ, Oishi, Sabrina, Piper, Michael, Harvey, Tracey J, Harvey, Tracey J., Premaratne, Susitha, Wood, Stephen A, Iyer, Swati, Premarathne, Susitha, Burne, Thomas H. J., Alexander, Suzanne   +12 more
core   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source