Results 171 to 180 of about 72,047 (256)
Abstract Background Friedreich ataxia (FA) is characterized by progressive degeneration of the cerebellum and its output pathways, particularly the dentato–thalamo–cortical system, leading to motor impairment and the cerebellar cognitive affective syndrome (CCAS).
Naeije Gilles +2 more
wiley +1 more source
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source
“Excessive L‐methionine (L‐met) intake impairs spatial (NOL) and recognition (NOR) memory, suppresses cell proliferation and vascular‐associated proliferating cells (Ki‐67 and Ki‐67/RECA‐1) and neuronal survival (BrdU/NeuN), and increases cell‐cycle arrest (p21) in the hippocampal dentate gyrus of adult rats.
Salinee Naewla +7 more
wiley +1 more source
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton +6 more
wiley +1 more source
Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea
Generation and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Michael R. Williamson +13 more
wiley +1 more source
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo +6 more
wiley +1 more source
Reelin and Notch1 Cooperate in the Development of the Dentate Gyrus
The development of the hippocampal dentate gyrus is a complex process in which several signaling pathways are involved and likely interact with each other.
Basak, O. +4 more
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