Results 171 to 180 of about 76,364 (261)

Postnatal development of the dentate gyrus vascular niche. [PDF]

Sci Rep
Devasthali N, Carter I, Saulsbery AI, Kirby ED.   +3 more
europepmc   +1 more source

Hippocampal GFAP in aging: Associations with AD and LATE‐NC pathologies and cognitive decline in older adults

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker for Alzheimer's disease (AD) progression in clinical studies, yet the role of brain GFAP in AD/AD‐related dementias (ADRD) pathologies and cognitive decline remains unclear. METHODS GFAP burden from CA1‐subiculum of the hippocampus were quantified.
Sonal Agrawal, Lei Yu, Sue E. Leurgans, Jialiang Li, Alifiya Kapasi, Puja Agarwal, Jeffrey L. Dage, Lisa L. Barnes, David A. Bennett, Patricia Boyle, Julie A. Schneider   +10 more
wiley   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy. [PDF]

Mol Psychiatry
Oh SJ, Jang JH, Roussarie JP, Jang GU, Jeong MS, Jo YS, Shin CH, Choi H, Lee K, Yoon JH, Oh YS.   +10 more
europepmc   +1 more source

Sex‐ and Region‐Specific Glial Reactivity in Hyperthyroid Mice Lacks Correlation With the Noncognitive and Non‐Depressive‐Like Behavioral Alterations

Brain and Behavior, Volume 16, Issue 6, June 2026.
Hyperthyroidism induces sex‐ and region‐specific glial reactivity without correlation to the noncognitive, non‐depressive behavioral changes in mice. ABSTRACT Background Glial reactivity is implicated in hyperthyroidism‐associated cognitive and psychiatric disorders, yet in vivo imaging evidence of glial reactivity in hyperthyroidism remains to be ...
Qianqian Xue, Zefang Lin, Yaofeng Wang, Xiuting Lin, Yun Yang, Chao Wang, Yuhong Ye, Weibing Miao   +7 more
wiley   +1 more source

Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation. [PDF]

J Neurochem
Colón LM, Famuyide OA, Eisch AJ.
europepmc   +1 more source

Massage Regulates Brain Plasticity in Chronic Sciatic Nerve Compression Injury Rats: A Study Based on Resting‐State Functional Magnetic Resonance Imaging

Brain and Behavior, Volume 16, Issue 6, June 2026.
Resting‐state functional magnetic resonance imaging analysis of chronic constriction injury rats after massage therapy. ABSTRACT Background Neuropathic pain (NP) is associated with maladaptive functional reorganization of the brain, yet the central mechanisms through which massage therapy exerts its analgesic effects remain poorly understood.
Lanting Huang, Xuekun Zhou, Lechun Chen, Chenyu Wang, Hao Wang, Huanzhen Zhang, Changzheng Jiang, Shuijin Chen, Jingjing Jiang, Qiangwen Xie, Zhigang Lin   +10 more
wiley   +1 more source

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula

Journal of Comparative Neurology, Volume 534, Issue 6, June 2026.
Mu opioid receptor (MOR) mRNA was detected with RNAscope in situ hybridization for Oprm1 and protein was detected with immunocytochemistry to map the distributions across the anterior‐posterior extent of the rat and mouse habenula. Expression distribution was also characterized in a transgenic reporter mouse line (Oprm1‐Venus/Venus) as an additional ...
Aashka K. Popat, Rhiana C. Simon, Beatriz B. Aoyama, Ahana Wokhlu, Aliza T. Ehrlich, Corey C. Harwell, Elyssa B. Margolis   +6 more
wiley   +1 more source

Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons. [PDF]

Neuropsychopharmacology
Santiago AN, Saval JC, Nguyen P, Chung HM, Khan S, Luna VM, Hen R, Chang WL.   +7 more
europepmc   +1 more source

LRP1 Activation Promotes Metabolic Reprogramming and Mrc1 Expression to Attenuate LPS‐Induced Cognitive Deficits: An Integrated Omics Analysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
LPS triggers neuroinflammation within the central nervous system. Conversely, the activation of LRP1 by SP16 mitigates insulin resistance, improves glucose metabolism, and facilitates the polarization of microglia toward an anti‐inflammatory M2‐like phenotype, which collectively contribute to the restoration of cognitive function.
Mengyao Qu, Yanan He, Lu Yu, Huikai Yang, Yixun Lu, Yingfu Li, Rui Wang, Miao Sun, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source