Results 181 to 190 of about 62,950 (262)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Moderate Exercise Stimulates PACAP-Mediated Neurogenesis in Rat Dentate Gyrus and Cerebellar Cortex. [PDF]

J Funct Morphol Kinesiol
Maugeri G, Di Bartolo S, Palmeri N, D'Amico AG, Brancato D, Federico C, D'Agata V, Musumeci G.   +7 more
europepmc   +1 more source

Longitudinal effects of physical activity on sleep in association with hippocampal‐amygdala subfield structure and functional connectivity in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Sleep is a modifiable risk factor in Alzheimer's disease (AD), but its relationship to medial temporal lobe (MTL) subfields and responsiveness to lifestyle interventions remain unclear. METHODS In the Dementia‐Multi‐Objective Validation of Exercise (MOVE) study, 46 individuals on the AD continuum were randomized to 6 months of ...
Ravi Dadsena, Ana S. Costa, Shari David, Luisa Haberl, Jörg B. Schulz, Kathrin Reetz, Alexa Haeger   +6 more
wiley   +1 more source

MSI2 in the dentate gyrus and ovary regulates the reproductive endocrine homeostasis of female mice. [PDF]

Commun Biol
Liu H, Li P, He Y, Yu M, Zhang Z, Li X, Zhu H, Teng B, Fan J, Yin J, Yang W, Hao Q, Chen Y, Li Y, Ren J, Cao G, Liu S, Li H, Du C.   +18 more
europepmc   +1 more source

Classification of tau status with machine learning models in amyloid‐positive cohorts

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Although tau positron emission tomography (PET) imaging is effective for staging tau pathology, it is limited clinically by cost and availability. Machine learning models based on magnetic resonance imaging (MRI)– and amyloid PET–derived features may serve as useful screening tools for tau pathology.
Yun‐Chi Lin, Sheng‐Chieh Chiu, Rebecca Massey, Yu‐Hua Dean Fang, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease. [PDF]

CNS Neurosci Ther
Chen CP, Zhang T, E ED, Xu TY, Han Q, Gao X, Sun J, Huang Y, Yang JH, Zhang XQ.   +9 more
europepmc   +1 more source

Alpha‐B‐crystallin immunohistochemistry: A sensitive but non‐specific marker for epileptogenic lesions

Brain Pathology, Volume 36, Issue 5, September 2026.
Ekin Güney, Ilay Caliskan, Tara Saunders, Mercedes Paredes, Calixto‐Hope Lucas, Kanish Mirchia, Rufei Lu, Merryl Terry, Erika Cagampan, Melike Pekmezci, Andrew Bollen, Arie Perry, Cathryn R. Cadwell, Tarık Tihan   +13 more
wiley   +1 more source

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. METHODS We utilized in silico analyses of published databases, MIR155‐deleted and ‐overexpressing human induced pluripotent stem cell ...
Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich   +10 more
wiley   +1 more source

Median Raphe projection into the dorsal dentate gyrus modulates anxiety behavior and coping with learning under stress. [PDF]

Sci Rep
Quan J, Kriebel M, Anunu R, Snippe-Strauss M, Volkmer H, Richter-Levin G.   +5 more
europepmc   +1 more source

Characterization of [18F]SMBT‐1 binding substrates in Alzheimer's disease and related disorders: A postmortem biochemical and immunohistochemical study

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Neuroimaging studies report associations of amyloid beta (Aβ) positron emission tomography (PET) with [18F](S)‐(2‐methylpyrid‐5‐yl)‐6‐[(3‐fluoro‐2‐hydroxy)propoxy]quinoline ([18F]SMBT‐1), a novel reactive astrogliosis surrogate radiotracer with high affinity for monoamine oxidase B (MAO‐B) in Alzheimer's disease (AD).
Eric E. Abrahamson, Julia K. Kofler, Oscar L. Lopez, Anne D. Cohen, Alexandra Gogola, Howard J. Aizenstein, Thomas K. Karikari, Elliott J. Mufson, Victor L. Villemagne, Milos D. Ikonomovic   +9 more
wiley   +1 more source