Results 181 to 190 of about 111,284 (274)

Sparsification and decorrelation of granule cell activity in the dentate gyrus by noradrenaline. [PDF]

Commun Biol
Glovaci I, Mihály A, Vervaeke K, Hu H.
europepmc   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation. [PDF]

J Neurochem
Colón LM, Famuyide OA, Eisch AJ.
europepmc   +1 more source

The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis

Aging Cell, Volume 25, Issue 5, May 2026.
We provide the first human evidence that the exercise‐induced myokine irisin mediates the relationship between physical activity and hippocampal volume in older adults, with strongest effects in CA1, CA3 and CA4 subfields. These regions are critical for memory and particularly vulnerable to Alzheimer's disease.
Thomas Pace, Jacob M. Levenstein, Bonnie L. Quigley, Rhys Houston, Ana P. Bouças, Sophie C. Andrews   +5 more
wiley   +1 more source

Postnatal development of the dentate gyrus vascular niche. [PDF]

Sci Rep
Devasthali N, Carter I, Saulsbery AI, Kirby ED.   +3 more
europepmc   +1 more source

Alzheimer's disease and mixed pathologies as a hidden contributor to fatal hypothermia: A large‐scale forensic autopsy‐based study

Brain Pathology, Volume 36, Issue 3, May 2026.
We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata, Koji Yoshida, Ryo Tanaka   +2 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, Volume 36, Issue 3, May 2026.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α-astrocyte-SLC1A2 pathway. [PDF]

J Neuroinflammation
Zhang Y, Ni Z, Xia T, Zhang N, Shen P, Wang N, Bai Z, Ma Y, Wang R, Sun D, Li S, Huangfu C, Gao Y, Zhou W.   +13 more
europepmc   +1 more source

Frontotemporal dementia: Clinical aspects, genetics, and neuropathology of a family with a C9ORF72 expansion in Argentina

Brain Pathology, Volume 36, Issue 3, May 2026.
Immunohistochemistry for TDP‐43: (A)—Dentate gyrus; (B)—Temporal lobe. Abstract Frontotemporal dementia (FTD) is the second most common cause of early‐onset dementia, typically manifesting before the age of 65, with a mean onset at 58 years. FTD may encompass a spectrum of neurodegenerative disorders resulting from frontotemporal lobar degeneration ...
Karen Daniela Román, Carolina Agata Ardohain, Ezequiel I. Surace, Mónica Beatriz Mezmezian, Alejandro Levy, Alice Baez Lovera, Carlos Turizo, Marcos G. Sorbara, María M. Esnaola y Rojas, Gastón H. Graviotto, Gustavo Sevlever, Ricardo F. Allegri, Cecilia M. Serrano, Nahuel Magrath Guimet   +13 more
wiley   +1 more source

Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality. [PDF]

iScience
Estarellas C, Álvarez-Salvado E, Pérez-Cervera L, Caramés JM, Pérez-Montoyo E, López-Madrona VJ, Garcia-Hernandez R, Mirasso CR, Canals S.   +8 more
europepmc   +1 more source