Results 201 to 210 of about 72,047 (256)

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

ZBP1‐mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Metabolic stress increases Alzheimer's disease (AD) risk, but mechanisms linking metabolic dysfunction to neuroimmune dysregulation remain unclear. METHODS We assessed cognition in community‐dwelling participants and used high‐fat diet (HFD)‐fed 5xFAD mice, high glucose and high palmitate (HGHP)‐treated regulatory T cell (Treg) co‐
Shanshan Huang, Zengyu Zhang, Jiajie Xia, Mengqiu Deng, Fangzheng Chen, Meng Wang, Yuchao Fei, Zhiwen Jiang, Chenyu Lu, Jiayu Fu, Jingchun Guo, Houguang Zhou   +11 more
wiley   +1 more source

H3K9me3 inhibition reverses Alzheimer's progression by restoring synaptic and immune proteostasis across the brain–retina axis

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Epigenetic dysregulation is increasingly linked to aging and neurodegeneration, yet its contribution to retinal and brain pathology in Alzheimer's disease (AD) remains unclear. METHODS We quantified the repressive epigenetic mark histone H3 lysine 9 trimethylation (H3K9me3) in post mortem retinas and brains from donors spanning ...
Dieu‐Trang Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Yosef Koronyo, Julia Sheyn, Bhakta Prasad Gaire, Saba Shahin, Haoshen Shi, Oksana Chepurna, Miyah R. Davis, Jered W. Wilson, Stuart L. Graham, Vivek K. Gupta, Lon S. Schneider, Michael T. Kleinman, Tao Sun, Margaret Fahnestock, David A. Horne, Mehdi Mirzaei, Keith L. Black, Maya Koronyo‐Hamaoui   +20 more
wiley   +1 more source

The underlying neurobiology of social isolation and loneliness in middle‐older adults: A systematic review

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Social isolation and loneliness are distinct but overlapping dementia risk factors, though their underlying neurobiological mechanisms remain unclear. A systematic search identified 42 studies examining social isolation, loneliness, and neurobiological outcomes in middle‐aged and older adults, including structural and functional neuroimaging ...
Jade Guarnera, Katherine Kenyon, Neel Joshi, Karen Caeyenberghs, Michael Wheeler, Helen Macpherson   +5 more
wiley   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, Volume 100, Issue 4, Page 781-787, October 2026.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Atypical Cerebellar Responses are Associated with Altered Neural Habituation during Sensory Stimulation in Autism

Autism Research, Volume 19, Issue 10, October 2026.
ABSTRACT Sensory processing atypicalities are highly prevalent in autistic youth; yet, the neural mechanisms underlying these differences are not well understood. While the cerebellum plays a key role in sensorimotor coordination and is structurally and functionally atypical in the autistic brain, it has been overlooked in research investigating ...
Melis E. Cakar, Kaitlin K. Cummings, Susan Y. Bookheimer, Mirella Dapretto, Shulamite A. Green   +4 more
wiley   +1 more source

Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy

Brain and Behavior, Volume 16, Issue 10, October 2026.
Proteomic profiling of the somatosensory cortex revealed that ketogenic diet was associated with remodeling of cortical protein networks in GAERS absence epilepsy, with altered proteins enriched in synaptic and mitochondrial pathways. ABSTRACT Purpose This study investigated the effects of ketogenic diet (KD) intervention on the cortical proteome in ...
Aslihan Gunel, Ulku Guler, Aylin Toplu, Nazli Busra Acikgoz, Bora Onat, Ariorad Moniri, Bekir Salih, Osman Ugur Sezerman, Filiz Onat   +8 more
wiley   +1 more source

Naoxueshu Oral Liquid Attenuates Early Radiation‐Induced Brain Injury in Rats

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Objective To investigate the effect of Naoxueshu Oral Liquid on rats with radiation‐induced brain injury. Methods A total of 108 male Sprague–Dawley rats were randomly assigned to a control group, an irradiated + normal saline group (RBI+NS), and an irradiated + Naoxueshu Oral Liquid group (RBI+NXS).
Fuguang Li, Xiaolong Qu, Kuiyuan Li, Guosong Li, Shifang Zhou, Min Zhao, Chunyu Zhang, Lei Hui, Wenchao Li   +8 more
wiley   +1 more source

Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In aged rats, 6‐month SXZ treatment reversed spatial memory deficits and preserved hippocampal integrity. Mechanistic assays show that SXZ promotes glutathione metabolism and inhibits ferroptosis via p53/SLC7A11/GPX4 and Keap1/Nrf2/HO‐1 pathways. SXZ is a novel neuroprotective agent against age‐related cognitive decline.
Mengya Liu, Shunyi Li, Yonglin Liang, Yugui Zhang, Xutong Jia, Yongqiang Duan, Min Bai   +6 more
wiley   +1 more source