Environmental enrichment is associated with enhanced novel object recognition performance and an increased proportion of smooth endoplasmic reticulum-containing spines in the dentate gyrus of Septin3<sup>-/-</sup> mice. [PDF]
Mol BrainAgeta-Ishihara N +4 more
europepmc +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1661-1673, August 2026.Single prolonged stress (SPS) induces post‐traumatic stress disorder (PTSD)‐like neuropathology characterized by oxidative stress, neuroinflammation, astrocytic reactivity, neuronal damage, and reduced neurotrophic support in the hippocampus, amygdala, and prefrontal cortex. Hesperidin counteracts these effects by attenuating lipid peroxidation and pro‐
Godson Emeka Anyanwu +6 more
wiley +1 more source
Overexpression of FoxO3a in the dentate gyrus alleviates CUS-induced anxiety- and depression-like behaviors and cognitive impairment. [PDF]
Behav Brain FunctYi S +6 more
europepmc +1 more source
Brain and Behavior, Volume 16, Issue 8, August 2026.ABSTRACT Background Approximately 30% of epilepsy patients develop pharmacoresistant epilepsy (PRE), characterized by persistent seizures refractory to antiseizure medications (ASMs). While neuroinflammation is implicated in both epileptogenesis and treatment failure, its precise temporal contribution remains unclear.
Xianmei Wang +5 more
wiley +1 more source
Partial Deletion of <i>Cxcl12</i> from Hippocampal Cajal-Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors. [PDF]
eNeurovan Bruggen R +4 more
europepmc +1 more source
A neuro‐behavioural model of neophobia
Biological Reviews, Volume 101, Issue 4, Page 1863-1876, August 2026.ABSTRACT Fear can be defined as the internal neurological state that releases a repertoire of behaviours an animal performs to reduce the effect of an aversive factor. Neophobia, the fear of novelty, is a fundamental behavioural trait observed across a wide range of species from arthropods to humans.
Arik Dorfman, Aziz Subach, Inon Scharf
wiley +1 more source
Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices. [PDF]
HippocampusShu WC, Jackson MB.
europepmc +1 more source
Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx ...
Luis Puelles, Elena Garcia‐Calero
wiley +1 more source
Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory. [PDF]
iScienceWilmerding LK +4 more
europepmc +1 more source
Brain‐Wide Mapping and Synaptic Localization of C1QL3 Using a Novel Epitope‐Tagged Knock‐In Mouse
Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.C1QL3 is a secreted adhesion molecule that acts as a key regulator of synaptic structure and function. We generated and validated a novel epitope‐tagged knock‐in mouse line (C1ql32HA) in which two hemagglutinin (HA) epitopes were inserted near the N‐terminus of the endogenous C1QL3 protein.
William P. Armstrong IV +12 more
wiley +1 more source