Results 221 to 230 of about 76,364 (261)

Human iPSC‐NSC‐Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease‐Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Intranasal administration of extracellular vesicles derived from human‐induced pluripotent stem cell‐derived neural stem cells in 5xFAD mice results in reduced oxidative stress, increased expression of proteins and genes associated with mitochondrial biogenesis and electron transport chain function, decreased mTOR activation, enhanced autophagy and ...
Leelavathi N. Madhu, Sahithi Attaluri, Sanya Kotian, Raghavendra Upadhya, Yogish Somayaji, Shama Rao, Prashant Tarale, Shruthi V. Ganesh, Charles Huard, Maheedhar Kodali, Bing Shuai, Vidya V. Rao, Ashok K. Shetty   +12 more
wiley   +1 more source

Partial Deletion of <i>Cxcl12</i> from Hippocampal Cajal-Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors. [PDF]

eNeuro
van Bruggen R, Manzanet Freyre K, Vasanthkumar S, Wang M, Tan Q.   +4 more
europepmc   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices. [PDF]

Hippocampus
Shu WC, Jackson MB.
europepmc   +1 more source

Dissociating role of Bassoon in glutamatergic and dopaminergic neurons in alcohol‐related behaviour and affective state in mice

British Journal of Pharmacology, Volume 183, Issue 11, Page 3111-3128, June 2026.
Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko, Mona Krenbauer, Janosh Isert, Marlon Kamlah, Thorben Tanzer, Hannes Rödel, Tobias Müller, Anil Annamneedi, Enes Yağız Akdaş, Volker Eulenburg, Bernd Lenz, Eckart D. Gundelfinger, Johannes Kornhuber, Anna Fejtova, Christian P. Müller   +14 more
wiley   +1 more source

CaMKII Neurons in the Dentate Gyrus Are Involved in Regulating Cognitive Impairment in Mice Induced by Stress Caused by Violence. [PDF]

Int J Mol Sci
Shao G, Liu D, Liu Z, Xiao Q, Shang Q, Qian H, Tu J, Liu X.   +7 more
europepmc   +1 more source

Non‐Isolated Dandy‐Walker Malformation: Exome Sequencing Efficacy and Phenotypic Expansions

Clinical Genetics, Volume 109, Issue 6, Page 1029-1037, June 2026.
Exome sequencing identified a diagnosis in 35% of 91 individuals with non‐isolated Dandy Walker malformation (DWM+). Only 24%–55% of these diagnoses could be made using a gene panel. We then demonstrated that DWM is a feature of disorders associated with ANKRD11, C2CD3, COL4A1, KMT2D, KRAS, OPHN1, SHOC2, SMARCB1, and WDR73.
Sarah Araji, Xiaonan Zhao, Jill A. Rosenfeld, Seema R. Lalani, Daryl A. Scott   +4 more
wiley   +1 more source

Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory. [PDF]

iScience
Wilmerding LK, Kondratyev I, Shi WB, Ramirez S, Hasselmo ME.   +4 more
europepmc   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, Volume 59, Issue 6, June 2026.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Impaired WNT3/IGF-1 Signaling in Dorsal Dentate Gyrus Contributes to Chronic Pain-Related Cognitive Impairment. [PDF]

CNS Neurosci Ther
An Y, Wu Y, Li X, Zhou T, Liu H, Xiao Y, Lai W, Qiu Y, Wei X.   +8 more
europepmc   +1 more source