Results 211 to 220 of about 62,950 (262)

CaMKII Neurons in the Dentate Gyrus Are Involved in Regulating Cognitive Impairment in Mice Induced by Stress Caused by Violence. [PDF]

Int J Mol Sci
Shao G, Liu D, Liu Z, Xiao Q, Shang Q, Qian H, Tu J, Liu X.   +7 more
europepmc   +1 more source

Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Chronic smoking during adolescence impairs glymphatic transport, leading to cognitive decline and aberrant accumulation of phosphorylated tau in the hippocampal DG region. Smoking‐induced glymphatic dysfunction compromises synaptogenesis and neurogenesis in the hippocampal DG region.
Chuanxiang Lv, Chengyu Xia, Zean Li, Tao Liu, Zhuang Sha, Shiying Dong, Yu Qian, Mingqi Liu, Kang Zhang, Xinran Zhang, Rongcai Jiang, Li Bie   +11 more
wiley   +1 more source

Impaired WNT3/IGF-1 Signaling in Dorsal Dentate Gyrus Contributes to Chronic Pain-Related Cognitive Impairment. [PDF]

CNS Neurosci Ther
An Y, Wu Y, Li X, Zhou T, Liu H, Xiao Y, Lai W, Qiu Y, Wei X.   +8 more
europepmc   +1 more source

A Novel Nogo‐A Receptor Antagonist Peptide Impedes Alzheimer's Disease Pathology by Nogo‐A/NgR/ROCK Signaling Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
NAP2, a NgR1 antagonist peptide, improved cognition in APP/PS1 mice, reduced Aβ plaques and tau hyperphosphorylation, increased dendritic spine density, and alleviated mitochondrial damage, acting through inhibition of the Nogo‐A/NgR/ROCK pathway, highlighting its therapeutic potential for Alzheimer's disease.
Zheng Zhang, Huimin Tan, Fang Shi, Jiajia Dai, Weilong Ding, Junliang Li, Yuke Wang, Rui Yang, Xinke Xu, Cheng Chen, Fei Xiao, Li‐an Huang, Xiaoyan Liu, Rui Liao, Li Yan   +14 more
wiley   +1 more source

Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks. [PDF]

Function (Oxf)
Saini S, Narayanan R.
europepmc   +1 more source

An Olfactory Piriform Cortex‐Lateral Hypothalamus Neural Circuit Contributes to Linalool‐Induced Analgesia

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Linalool odor exposure activates a glutamatergic projection from the piriform cortex to the lateral hypothalamus (PiriGlu‐LH), mediating descending inhibitory pain pathways. This demonstrates a novel neural mechanism for olfactory‐induced pain modulation and suggests potential therapeutic implications for pain management.
Yunhe Zhu, Jingping Sun, Shan Wang, Qidong Zhang, Jian Mao, Guobi Chai, Qingzhao Shi, Wu Fan, Jianping Xie   +8 more
wiley   +1 more source

Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype. [PDF]

Int J Neuropsychopharmacol
Shoji H, Hagihara H, Graef IA, Crabtree GR, Huang FL, Frankland PW, Miyakawa T.   +6 more
europepmc   +1 more source

Neuromodulation Techniques in Chronic Cerebral Hypoperfusion: Mechanisms and Therapeutic Advances

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Chronic cerebral hypoperfusion drives vascular cognitive impairment through neurovascular dysfunction, white matter injury, neuroinflammation, oxidative stress and synaptic network failure. Neuromodulation may offer a multi‐target strategy to restore plasticity, improve functional connectivity and support cognitive recovery. ABSTRACT Background Chronic
Chenye Qiao, Ning Li, Congxiao Wang, Yingpeng Wang, Jinglu Li, Hujun Wang, Zongjian Liu, Shuyan Qie   +7 more
wiley   +1 more source

Intranasal Administration of an Arginine‐Enriched Penetratin Peptide Confers Neuroprotection via Mitochondrial Functional Modulation in a Genetic Parkinson's Disease Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Intranasal PenArg achieved broad brain delivery and improved mitochondrial function in a UQCRC1‐mutant Parkinson's disease model. Chronic treatment preserved dopaminergic neurons, improved motor performance, reduced neuroinflammatory and systemic inflammatory responses, and attenuated skeletal muscle pathology.
Jui‐Chih Chang, Cheng‐Yi Yeh, Kai‐Li Liu, Yi‐Chun Chao, Chin‐Hsien Lin, Chin‐San Liu   +5 more
wiley   +1 more source

Differential Astrocyte-Supplied NMDAR Co-Agonist for CA1 Versus Dentate Gyrus Long-Term Potentiation. [PDF]

Hippocampus
Sateesh S, Abraham WC.
europepmc   +1 more source