Results 211 to 220 of about 76,364 (261)

Environmental enrichment is associated with enhanced novel object recognition performance and an increased proportion of smooth endoplasmic reticulum-containing spines in the dentate gyrus of Septin3^-/- mice. [PDF]

Mol Brain
Ageta-Ishihara N, Fuse N, Suzuki A, Fukazawa Y, Kinoshita M.   +4 more
europepmc   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations. [PDF]

Nat Neurosci
Cholvin T, Bartos M.
europepmc   +1 more source

Loss of Brain‐Derived Estrogen Is Associated With Sex‐ and Age‐Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression

Aging Cell, Volume 25, Issue 6, June 2026.
Age, sex, and estrogen loss are widely recognized risk factors for Alzheimer's disease. Here, we show that brain‐specific aromatase knockout (bArKO) and the resulting estrogen loss lead to memory impairment, reduced social interaction, and extracellular environment dysregulation selectively in aged female mice, but not in young female or male mice ...
Natalie C. Piehl, Ariel W. Halle, Guadalupe Rodriguez, Andrea Locci, Stacy Kujawa, Caroline Haywood, John Coon V, Ross P. McNally, Zaina A. Karim, Tianming You, Hongxin Dong, Serdar E. Bulun, Hong Zhao   +12 more
wiley   +1 more source

Lifetime Variations in Prolactin Expression in the Hippocampus and Dentate Gyrus of the Rat. [PDF]

Int J Mol Sci
Carretero-Hernández M, Herráez E, Catalano-Iniesta L, Hernández-González D, Díez-Castro D, Rodríguez-Vicente AE, García-Barrado J, Vicente-García T, Robles-García M, Blanco EJ, Carretero J.   +10 more
europepmc   +1 more source

Restoring Septohippocampal Cholinergic Signaling Rescues Surgery‐Induced Neurogenesis and Memory Deficits in Aged Mice

Aging Cell, Volume 25, Issue 6, June 2026.
Surgery‐induced MS/vDB → DG cholinergic decline impairs hippocampal neurogenesis and memory in aged mice; galantamine‐mediated cholinergic potentiation or sustained chemogenetic activation rescues these deficits, highlighting therapeutic potential for POCD.
Lei Lei, Qingsheng Meng, Xiaoyu Hu, Jinjin Yang, Ni Du, Songxue Su, Kenji Hashimoto, Jing Cao, Jian‐jun Yang   +8 more
wiley   +1 more source

Overexpression of FoxO3a in the dentate gyrus alleviates CUS-induced anxiety- and depression-like behaviors and cognitive impairment. [PDF]

Behav Brain Funct
Yi S, Yang B, Zhang X, Zhao B, Wei L, Yao Z, Zhang R.   +6 more
europepmc   +1 more source

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

N-acetylcysteine Restores Impaired Dentate Gyrus Neurogenesis in a Neonatal Maternal Separation Rat Model. [PDF]

Exp Neurobiol
Kim HB, Kim YJ, Lim HM, Suh SW, Lee JH, Lee CJ, Woo RS.   +6 more
europepmc   +1 more source