Results 191 to 200 of about 62,950 (262)

Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition. [PDF]

J Neurochem
D'Andrea G, Bertini L, Costanzi M, Canini F, Bernini R, Fochetti A, Clemente M, Proietti S, Ceccarelli M, Caruso C, Caruso M, Scavizzi F, Raspa M, Tirone F, Micheli L.   +14 more
europepmc   +1 more source

Brain morphometry patterns in the presence of Alzheimer's disease and/or LATE neuropathologic changes

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Alzheimer's disease neuropathologic change (ADNC) and limbic‐predominant age‐related transactive response DNA‐binding protein 43 kDa (TDP‐43) encephalopathy neuropathologic change (LATENC) are common in older adults, yet differences in brain morphometry patterns when one or both pathologies are present remain unclear.
Khalid Saifullah, Abdur Raquib Ridwan, Arnold M. Evia, Sue E. Leurgans, Maude Wagner, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +7 more
wiley   +1 more source

Dentate gyrus network regulation by somatostatin- and parvalbumin-expressing interneurons differentially impacts spatial memory processing. [PDF]

iScience
Raven F, Vankampen AA, He A, Aton SJ.
europepmc   +1 more source

Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage‐informed framework in which rapid eye movement (REM) sleep‐related respiratory events amplify vascular ...
Destiny E. Berisha, Ruth M. Benca, Bryce A. Mander   +2 more
wiley   +1 more source

Lifetime Variations in Prolactin Expression in the Hippocampus and Dentate Gyrus of the Rat. [PDF]

Int J Mol Sci
Carretero-Hernández M, Herráez E, Catalano-Iniesta L, Hernández-González D, Díez-Castro D, Rodríguez-Vicente AE, García-Barrado J, Vicente-García T, Robles-García M, Blanco EJ, Carretero J.   +10 more
europepmc   +1 more source

Genetic frontotemporal degeneration across the lifespan? A critical appraisal of the neurodevelopmental hypothesis

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Potential neurodevelopmental effects of genetic frontotemporal degeneration (FTD)‐related variants have been postulated by observational studies over the past 25 years. Recent data from large FTD cohort studies have delineated biological and phenotypic characteristics of presymptomatic stages of disease, with some genetic variants showing ...
Isis So, Timothy J. Y. Birkle, Karen E. Duff, Miguel Restrepo‐Martinez, Simon Ducharme, Elizabeth C. Finger   +5 more
wiley   +1 more source

N-acetylcysteine Restores Impaired Dentate Gyrus Neurogenesis in a Neonatal Maternal Separation Rat Model. [PDF]

Exp Neurobiol
Kim HB, Kim YJ, Lim HM, Suh SW, Lee JH, Lee CJ, Woo RS.   +6 more
europepmc   +1 more source

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Down syndrome (DS) is caused by a complete or partial trisomy of chromosome 21, resulting in variable intellectual disabilities and a high risk for early‐onset Alzheimer's disease (DS‐AD). Dysregulation of the mammalian target of rapamycin (mTOR) and insulin (INS) signaling pathways has been reported in DS.
Abigail J. Nordbeck, Mitchell Martá‐Ariza, Henric Ek Olofsson, Evgeny Kanshin, Beatrix Ueberheide, Ken Jones, Bridget Sanford, Eric D. Hamlett, Elizabeth Head, Elliott J. Mufson, Sylvia E. Perez, Thomas Wisniewski, Samuel Guzman, Ann‐Charlotte Granholm   +13 more
wiley   +1 more source

The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations. [PDF]

Nat Neurosci
Cholvin T, Bartos M.
europepmc   +1 more source

Aberrant ɑSMA expression reveals broad mossy fiber reorganization integrating with tangle and plaque formation and mitoenergetic alteration in the human hippocampus

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Neural network and bioenergetic abnormalities occur with Alzheimer's disease (AD) pathogenesis. METHODS We explored mossy fiber (MF) and mitoenergetic alteration using ɑ‐smooth muscle actin (ɑSMA) and cytochrome c oxidase (COX) immunolabeling in human hippocampus relative to tangle and plaque formation by referring to Braak (0–VI)
Tian Tu, Qi‐Lei Zhang, Zhong‐Ping Sun, Chao Kang, Dan Li, Xin‐Hua Huo, Xiao‐Jie Zhang, Yan Zhang, Mengchao Cui, Aihua Pan, Jian Wang, Xiao‐Xin Yan   +11 more
wiley   +1 more source