Results 161 to 170 of about 76,364 (261)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Stress-Enhanced Fear Learning (SEFL) Is Associated With Enhanced Reactivation of Fear Engrams in Caudal But Not Rostral Dentate Gyrus. [PDF]

Hippocampus
Paredes D, Drew MR.
europepmc   +1 more source

Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far‐Red Light Involving Triplet Sensitization in an Aqueous System

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The action spectrum of a tailored azobenzene is shifted toward bio‐optical window through the chemical modification of its singlet and triplet energy levels. Consequently, the bidirectional photo‐switching of azobenzene in physiological conditions is achieved when excited by red and far‐red light, which offers greater tissue penetration.
Mila Miroshnichenko, Helen Hölzel, Edvinas Orentas, Karolis Kazlauskas, Pedro Ferreira, Fabienne Dumoulin, Carles Alcaide, Miquel Solà, Roger Bresolí‐Obach, Santi Nonell, Pankaj Bharmoria, Kasper Moth‐Poulsen   +11 more
wiley   +1 more source

Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice. [PDF]

iScience
Canela M, Adell JB, Coll DR, González-Parra JA, Pinho JS, Busquets-García A.   +5 more
europepmc   +2 more sources

Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice. [PDF]

Neuron
Hainmueller T, Heynold EA, Paleologos N, Raikov IG, Soltesz I, Buzsáki G.   +5 more
europepmc   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Postnatal neurogenesis in the dentate gyrus of the guinea pig

, 2005
In all species examined, the dentate gyrus develops over an extended period that begins during gestation and continues up to adulthood. The aim of this study was to investigate the pattern of postnatal cell production in the dentate gyrus of the guinea ...
GUIDI, SANDRA, BARTESAGHI, RENATA, CONTESTABILE, ANTONIO, CIANI, ELISABETTA, SEVERI S.   +4 more
core  

Endogenously generated Dutch‐type Aβ non‐fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract BACKGROUND APPE693Q (“Dutch”) transgenic mice develop aging‐related learning deficits and accumulate endogenously generated non‐fibrillar aggregates (NFAs) of amyloid beta (Aβ) and amyloid precursor protein α‐carboxy terminal fragments. NFA‐Aβ correlates with synaptic loss and memory deficits more closely than does fibrillar Aβ.
Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Tripathi, Yong Huang, Akiko Asada, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan van de Loo, Cheryl D. Stimpson, Ronan Talty, Charles Glabe, Efrat Levy, Minghui Wang, Marjan Ilkov, Toshiharu Suzuki, Kanae Ando, Bin Zhang, Lars Lannfelt, Brigitte Guérin, William D. Lubell, Shai Rahimipour, Dara L. Dickstein, Sam Gandy, Ottavio Arancio, Michelle E. Ehrlich   +28 more
wiley   +1 more source

Perisomatic innervation on the semilunar granule cells and outer molecular layer granule cells of the dentate gyrus of the mouse. [PDF]

Front Neuroanat
Rovira-Esteban L, Vieco-Martí I, Herraiz-Cabanes J, Varea E, Nacher J, Crespo C, Blasco-Ibáñez JM.   +6 more
europepmc   +1 more source

Emerging directions in tauopathy research

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Luc Buée, Kristin R. Wildsmith, Suvarna Alladi, Taylor Bertucci, Delphine Boche, Kathryn R. Bowles, Adam Boxer, Jennifer Brummet, Sarah L. DeVos, Kristophe Diaz, Anna Jane Dreyer, Karen Duff, Claudia Duran‐Aniotz, Claire S. Durrant, Kurt Farrell, Igor C. Fontana, Nicolai Franzmeier, Bess Frost, Kanta Horie, Petr Kaňovský, Aimee W. Kao, Simin Mahinrad, Maura Malpetti, Huw R. Morris, Carla Palleis, Leonard Petrucelli, Jessica Rexach, Larisa Reyderman, Amy Rommel, James B. Rowe, Sandra M. Sanabria Bohórquez, Chihiro Sato, Michael Schöll, Anja Schneider, Rohan de Silva, Heather M. Snyder, Lawren VandeVrede, Andrew W. Varga, Jacob W. Vogel, Felix L. Yeh, Andrew S. Yoo, Maria C. Carrillo   +41 more
wiley   +1 more source