Results 131 to 140 of about 72,047 (256)

Long‐Term Blood Pressure Variability, Hippocampal Subfield Volume and Cognitive Decline: A Population‐Based Prospective MRI Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Long‐term blood pressure variability (BPV) is associated with cognitive decline, yet the underlying mechanisms have not been fully elucidated. Purpose To investigate the associations between long‐term BPV and hippocampal subfield volume and cognitive function and to assess the mediation effect of hippocampal subfield volume.
Fei Li, Jing Chen, Huijing Shi, Ling Yang, Xianyu Zhu, Rui Li, Xinyu Zhao, Xiaoliang Liang, Shun Zhang, Yaping Zhang, Han Lv, Jing Li, Shuohua Chen, Yuntao Wu, Ying Hui, Shouling Wu, Zhenchang Wang, Xiaoshuai Li   +17 more
wiley   +1 more source

Limbic Structural Alterations and Structural Covariance Across Prodromal Phenotypes and Early Parkinson's Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Non‐motor symptoms may precede motor diagnosis in Parkinson's disease (PD), but whether distinct prodromal phenotypes exhibit differential limbic structural alterations remains unclear. Purpose To investigate limbic structural alterations across prodromal PD phenotypes defined by rapid eye movement sleep behavior disorder (RBD) and ...
Yuanyuan Zhao, Luoyu Wang, Yihan Suo, Maoling Liu, Yi Lin, Lidan Fang, Zhongxiang Ding   +6 more
wiley   +1 more source

Transformation of spatial representations along hippocampal circuits

iScience
Summary: The hippocampus is thought to provide the brain with a cognitive map of the external world by processing various types of spatial information.
Bérénice Gandit, Lorenzo Posani, Chun-Lei Zhang, Soham Saha, Cantin Ortiz, Manuela Allegra, Christoph Schmidt-Hieber   +6 more
doaj   +1 more source

Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (18F) Positron Emission Tomography

Movement Disorders, EarlyView.
Abstract Background Florzolotau (18F) positron emission tomography (florzolotau PET) enables high‐contrast in vivo detection of four‐repeat tau pathology in progressive supranuclear palsy (PSP), but whether longitudinal tau imaging reflects disease progression remains unclear.
Yoshikazu Chishiki, Kenji Tagai, Yuko Kataoka, Ryoji Goto, Kenta Osawa, Asaka Oyama, Hideki Matsumoto, Masanori Ichihashi, Yuki Momota, Tetsuji Kamada, Chie Seki, Kiwamu Matsuoka, Kosei Hirata, Shin Kurose, Sho Moriguchi, Yuki Komatsu, Hideo Kato, Yasuharu Yamamoto, Yoshikazu Nakano, Shigeki Hirano, Hitoshi Shinotoh, Hitoshi Shimada, Tokahiko Tokuda, Kazunori Kawamura, Ming‐Rong Zhang, Keisuke Takahata, Makoto Higuchi, Hironobu Endo   +27 more
wiley   +1 more source

Entwicklungsneuroplastizität im Hippokampus : ein Zusammenspiel limbo-präfrontaler Schaltkreise [PDF]

, 2009
Schäfers ATU. Developmental neuroplasticity in the hippocampus : an interplay of prefrontal-limbic circuits. Bielefeld (Germany): Bielefeld University; 2009.Neuroplastizität, die Fähigkeit des Gehirns, auf umweltbedingte und intrinsiche Stimulation zu ...
Schäfers, Andrea T. U.
core  

Cortical Cholinergic Pathway Degeneration Reflects Cognitive Impairment and Dementia in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Cognitive impairment is a prevalent and debilitating feature of Parkinson's disease (PD). Increasing evidence from postmortem and in vivo positron emission tomography imaging studies supports cholinergic dysfunction in PD. There is, however, little evidence regarding the influence of the structural integrity of cortical cholinergic ...
Nicola M. Slater, Daniel J. Myall, Reza Shoorangiz, Wassilios G. Meissner, Ian J. Kirk, Ross J. Keenan, Rebecca M. Lee, Kyla‐Louise Horne, Michael R. MacAskill, Campbell J. Le Heron, Toni L. Pitcher, Tim J. Anderson, Tracy R. Melzer, John C. Dalrymple‐Alford   +13 more
wiley   +1 more source

HE-staining of dentate gyrus at each developmental stage.

, 2014
(A) HE-staining of dentate gyrus in five-week-old mice. Bars  = 50 μm. a, ZFP521+/+ mouse; b, ZFP521Δ/Δ mouse. Note that the density of neuronal cells was obviously lower and the neuronal cell layer was more obscure in ZFP521Δ/Δ mouse. (B) HE-staining of
Etsuko Matsubara (543875), Yoji Suzuki (543878), Rie Akazawa (543876), Masaki Yasukawa (28387), Seiji Matsuda (485036), Nobutaka Ohkubo (543874), Noriaki Mitsuda (543880), Mamoru Aoto (543877), Takaya Abe (106442), Hiroshi Kiyonari (106447), Jun Yamanouchi (28385), Ikuya Sakai (543879)   +11 more
core   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Spine morphology of molecular layer of dentate gyrus.

, 2015
(A) Graphical representation of spine density/30μm of molecular layer of dentate gyrus; (B) Representative images of DIL dye staining of of molecular layer of dentate gyrussubarea where the mushroom spines are represented by yellow colour, thin spines by
Sunetra Sase (814052), Ajinkya Sase (814054), Harald Höger (206871), Marion Gröger (264663), Gert Lubec (170911), Rasha Refaat Mahmmoud (814051), Maher Mokhtar (814055), Yogesh D. Aher (814053)   +7 more
core   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source