Results 111 to 120 of about 62,950 (262)

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

The dentate gyrus in depression: directions for future research [PDF]

Molecular Psychiatry, 2020
Jasper O. Nuninga, René C. W. Mandl, Iris E. C. Sommer   +2 more
openaire   +2 more sources

“White and Clear” (WaC): A tunable hydrophilic tissue clearing strategy for multi‐species 3D imaging

VIEW, EarlyView.
Optical tissue clearing methods help scientists make tissues transparent to image structures deep inside organs in 3D, but many existing techniques are limited in performance and difficulty. In this study, we developed an optimized clearing method called WaC (White and Clear), which improves upon existing techniques by combining efficient tissue ...
Vicente Llorente, Elena Fernández‐Cortés, Daniel Sanderson, Julia Carolina Salazar Romero, Juan Miguel Gil‐Jaurena, Esther Bernaldo‐de‐Quirós, Rafael J. Jiménez‐Riobóo, Rafael Correa‐Rocha, Isabel Izquierdo‐Barba, Rafael Samaniego, Jorge Ripoll, Manuel Desco, María Victoria Gómez‐Gaviro   +12 more
wiley   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source

Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy

Neurobiology of Disease
Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ...
Wenxi Yu, Sophie F. Hill, Limei Zhu, Yiannos Demetriou, Faith Reger, Joanna Mattis, Miriam H. Meisler   +6 more
doaj   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source