Results 111 to 120 of about 72,047 (256)

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Theta oscillations (4–12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ‐aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigation, memory encoding, and sensorimotor integration during specific ...
Maxime Lévesque, Massimo Avoli
wiley   +1 more source

Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus

open access: yesNeural Plasticity, 2008
Long-term recognition memory requires protein synthesis, but little is known about the coordinate regulation of specific genes. Here, we examined expression of the plasticity-associated immediate early genes (Arc, Zif268, and Narp) in the dentate gyrus ...
Jonathan Soulé   +5 more
doaj   +1 more source

Toward a full-scale computational model of the rat dentate gyrus

open access: yesFrontiers in Neural Circuits, 2012
Recent advances in parallel computing, including the creation of the parallel version of the NEURON simulation environment, have allowed for a previously unattainable level of complexity and detail in neural network models.
Calvin James Schneider   +2 more
doaj   +1 more source

Mice ephys datasets for "Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing Dentate Gyrus functionality" Estarellas et al. 2026

open access: yes
The repository constains the datasets (PV) used in the publication: Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing Dentate Gyrus functionality.Peer ...
Canals, Santiago
core   +1 more source

The enigmatic mossy cell of the dentate gyrus [PDF]

open access: yesNature Reviews Neuroscience, 2016
Mossy cells comprise a large fraction of the cells in the hippocampal dentate gyrus, suggesting that their function in this region is important. They are vulnerable to ischaemia, traumatic brain injury and seizures, and their loss could contribute to dentate gyrus dysfunction in such conditions.
openaire   +2 more sources

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

open access: yesEpilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi   +4 more
wiley   +1 more source

Thioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats [PDF]

open access: yesVeterinary Research Forum, 2010
The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 µl, 2.5 %)
Emad Khalilzadeh   +3 more
doaj  

Rat ephys datasets for "Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing Dentate Gyrus functionality" Estarellas et al. 2026

open access: yes
The repository constains the datasets (LTP) used in the publication: Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing Dentate Gyrus functionality.Peer ...
Canals, Santiago
core   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

open access: yesEpilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Effect of interaventricular injection of Vitamin C on the histological structural of dentate gyrus of hipocampus in epileptic rats

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Hippocampus is the main region in cortex of the brain that involved in epilepsy. This study was done to determine the effect of intraventricular injection of vitamin C on histological structure of dentate gyrus of hipocampus in ...
R Golmohammadi, B Kmalimansh
doaj  

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