Results 91 to 100 of about 72,047 (256)

Structure, function, and plasticity of hippocampal dentate gyrus microcircuits [PDF]

, 2014
The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes.
Peter Jonas, Lisman, John, Peter eJonas, Jonas, Peter M ; https://orcid.org/, John eLisman, John Lisman   +5 more
core   +1 more source

PlexinA2 forward signaling through Rap1 GTPasesregulates dentate gyrus development andSchizophrenia-like behaviors

, 2023
Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG.
Püschel, AW, Korn, MJ, Jin, J, Parent, JM, Parent, R, Corfas, G, Wan, G, Giger, RJ, Kohen, R, Fisher, GL, Zhao, XF, Murphy, GG, Ji, L, Dolan, DF, Duan, Y   +14 more
core   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory. [PDF]

, 2017
Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus.
Conway, Myra E., Michael Knight, Kauppinen, Risto A., Newson, Margaret, Demitra Tsivos, Bryony McCann, Elizabeth J. Coulthard, Dillon, Serena E., Kauppinen, Risto, Shiel, Anna, Risto A. Kauppinen, Shiel, Anna I., Tsivos, Demi, Conway, Myra, Serena E. Dillon, Tsivos, Demitra, Catherine Pennington, Dillon, Serena, Newson, Margaret A., Coulthard, Elizabeth J., McCann, Bryony, Margaret A. Newson, Pennington, Catherine; id_orcid, Anna I. Shiel, Knight, Michael, Myra E. Conway, Coulthard, Liz, Pennington, Catherine   +27 more
core   +1 more source

Mossy fiber sprouting in the dentate gyrus [PDF]

Epilepsia, 2010
SummaryAberrant sprouting of granule cell axons is a common feature in temporal lobe epilepsy. An increasingly detailed picture of granule cell circuit changes has emerged, but the cause–effect relationship between mossy fiber sprouting and epileptogenesis remains unclear.
openaire   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

The CA3 “backprojection” to the dentate gyrus [PDF]

, 2007
The hippocampus is typically described in the context of the trisynaptic circuit, a pathway that relays information from the perforant path to the dentate gyrus, dentate to area CA3, and CA3 to area CA1. Associated with this concept is the assumption that most hippocampal information processing occurs along the trisynaptic circuit.
openaire   +2 more sources

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

Nature Communications
The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context,
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang, Marlene Bartos   +3 more
doaj   +1 more source

Electrophysiological properties of DCX-GFP-positive cells in the dentate gyrus (** p<0.01).

, 2013
Electrophysiological properties of DCX-GFP-positive cells in the dentate gyrus ...
Helmut Kettenmann (214707), Giselle Cheung (341954), Friederike Klempin (341952), Golo Kronenberg (341953), Gerd Kempermann (122767)   +4 more
core   +1 more source