Results 71 to 80 of about 111,284 (274)
Brain injury impairs dentate gyrus inhibitory efficacy
Neurobiology of Disease, 2007 Every 23 s, a person sustains a traumatic brain injury in the United States leaving many patients with substantial cognitive impairment and epilepsy.
David P. Bonislawski +2 more
doaj +1 more source
Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response [PDF]
, 2011 The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works.
Azami, N.S. +3 more
core
Parallel and convergent processing in grid cell, head-direction cell, boundary cell, and place cell networks. [PDF]
, 2013 The brain is able to construct internal representations that correspond to external spatial coordinates. Such brain maps of the external spatial topography may support a number of cognitive functions, including navigation and memory.
Brandon, Mark P +2 more
core +2 more sources
Synaptic Plasticity in the Human Dentate Gyrus [PDF]
The Journal of Neuroscience, 2000 Activity-dependent plasticity is a fundamental feature of most CNS synapses and is thought to be a synaptic correlate of memory in rodents. In humans, NMDA receptors have been linked to verbal memory processes, but it is unclear whether NMDA receptor-dependent synaptic plasticity can be recruited for information storage in the human CNS.
H, Beck +4 more
openaire +2 more sources
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis. [PDF]
PLoS ONE, 2015 The dentate gyrus is considered to function as an inhibitory gate limiting excitatory input to the hippocampus. Following status epilepticus (SE), this gating function is reduced and granule cells become hyper-excitable.
Sean P Flynn +4 more
doaj +1 more source
What is the functional role of adult neurogenesis in the hippocampus? [PDF]
, 2004 The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be.
Kempermann, Gerd +2 more
core +1 more source
Endocannabinoids in the dentate gyrus [PDF]
, 2007 Recent years have produced rapid and enormous growth in our understanding of endocannabinoid-mediated signaling in the CNS. While much of the recent progress has focused on other areas of the brain, a significant body of evidence has developed that indicates the presence of a robust system for endocannabinoid-mediated signaling in the dentate gyrus ...
openaire +2 more sources
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Modelling hippocampal neurogenesis across the lifespan in seven species
, 2011 The aim of this study was to estimate the number of new cells and neurons added to the dentate gyrus across the lifespan, and to compare the rate of age-associated decline in neurogenesis across species.
Lazic, Stanley E.
core +1 more source