Results 61 to 70 of about 72,047 (256)

Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis.

PLoS Biology, 2010
The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories.
Alfonso Lavado, Oleg V Lagutin, Lionel M L Chow, Suzanne J Baker, Guillermo Oliver   +4 more
doaj   +1 more source

Tutorial on adult dentate gyrus neurogenesis for machine learners

, 2018
Tutorial on adult dentate gyrus neurogenesis for machine ...
Gozel Olivia
core   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Vascular network of the dentate gyrus.

, 2013
(A) Representative microphotographs of the dentate gyrus showing the histochemistry for lectin Lycopersicon Esculentum. Scale bar corresponds to 100 µm. (B) Quantification of the lectin-positive fractional vascular area in the dentate gyrus.
Juan Beauquis (359752), Alejandro F. De Nicola (359757), Flavia Saravia (359759), Paulina Roig (359754)   +3 more
core   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Brain injury impairs dentate gyrus inhibitory efficacy

Neurobiology of Disease, 2007
Every 23 s, a person sustains a traumatic brain injury in the United States leaving many patients with substantial cognitive impairment and epilepsy.
David P. Bonislawski, Elizabeth P. Schwarzbach, Akiva S. Cohen   +2 more
doaj   +1 more source

Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis

Journal of Developmental Biology, 2020
We have previously described hypomorphic reelin (Reln) mutant mice, RelnCTRdel, in which the morphology of the dentate gyrus is distinct from that seen in reeler mice.
Seungshin Ha, Prem P. Tripathi, Ray A. Daza, Robert F. Hevner, David R. Beier   +4 more
doaj   +1 more source

Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats [PDF]

, 2007
Bacterial meningitis is associated with high rates of morbidity and mortality, despite advances in antibiotic therapy. Meningitis caused by Streptococcus pneumoniae is associated with a particularly high incidence of neurological sequelae including ...
Grandgirard, D, Tauber, Martin G., Pleasure, S J, Leib, Stephen L., Kummer, J, Bifrare, Y-D, Kummer J, Leib SL, Grandgirard D, Bifrare YD, Pleasure SJ, Tauber MG   +11 more
core   +2 more sources

The Dentate Gyrus: Its Value for Depression [PDF]

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021
Jasper O. Nuninga, Iris E.C. Sommer
openaire   +2 more sources