Results 51 to 60 of about 72,047 (256)
Frontiers in Molecular Neuroscience, 2023 Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain structures in both healthy and diseased brains. The tumor suppressor gene, phosphatase and tensin homolog deleted on chromosome 10 (Pten) has previously been found to ...
Sarah E. Latchney +4 more
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Evolution of the mammalian dentate gyrus [PDF]
Journal of Comparative Neurology, 2015 ABSTRACTThe dentate gyrus (DG), a part of the hippocampal formation, has important functions in learning, memory, and adult neurogenesis. Compared with homologous areas in sauropsids (birds and reptiles), the mammalian DG is larger and exhibits qualitatively different phenotypes: 1) folded (C‐ or V‐shaped) granule neuron layer, concave toward the hilus
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Dentate gyrus volume deficit in schizophrenia [PDF]
Psychological Medicine, 2019 AbstractBackgroundSchizophrenia is associated with robust hippocampal volume deficits but subregion volume deficits, their associations with cognition, and contributing genes remain to be determined.MethodsHippocampal formation (HF) subregion volumes were obtained using FreeSurfer 6.0 from individuals with schizophrenia (n= 176, mean age ±s.d.= 39.0 ...
Soichiro Nakahara +15 more
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A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Neurobiology of DiseaseParvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits.
Sang-Hun Lee +2 more
doaj +1 more source
Neurogenesis in the dentate gyrus: carrying the message or dictating the tone
Frontiers in Neuroscience, 2013 The dentate gyrus is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas.
Verónica C Piatti +2 more
doaj +1 more source
Data sets for recording in the dentate gyrus.
, 2013 Data sets for recording in the dentate gyrus.
Kumiko Uchiyama (503302) +5 more
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Expression of TLR8 in the dentate gyrus.
, 2022 Double immunofluorescence of TLR8 (red fluorescence; a, d, g) with the microglia marker transmembrane protein 119 (Tmem-119; b, c), the astrocyte marker glial fibrillary acidic protein (GFAP; e, f), and neuron-specific nuclear protein (NeuN; h, i), a ...
Meinrad Drexel (12501722) +3 more
core +1 more source
Microglia and neurogenesis in the epileptic dentate gyrus [PDF]
Neurogenesis, 2016 Microglia are recognized as major immune cells in the brain. They have been traditionally studied in various contexts of disease, where their activation has been assumed to induce mostly detrimental effects. Recent studies, however, have challenged the current view of microglia, clarifying their essential contribution to the development of neural ...
Cong, Luo, Yuji, Ikegaya, Ryuta, Koyama
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Advanced Science, EarlyView.Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang +7 more
wiley +1 more source