Results 31 to 40 of about 62,950 (262)
Microglia and neurogenesis in the epileptic dentate gyrus [PDF]
Neurogenesis, 2016 Microglia are recognized as major immune cells in the brain. They have been traditionally studied in various contexts of disease, where their activation has been assumed to induce mostly detrimental effects. Recent studies, however, have challenged the current view of microglia, clarifying their essential contribution to the development of neural ...
Cong, Luo, Yuji, Ikegaya, Ryuta, Koyama
openaire +2 more sources
Capicua regulates the development of adult-born neurons in the hippocampus
Scientific Reports, 2021 New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation.
Brenna Hourigan +4 more
doaj +1 more source
p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise
Frontiers in Cellular Neuroscience, 2019 In the neurogenic niches—the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles—stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus ...
Laura Micheli +6 more
doaj +1 more source
Adult-born neurons add flexibility to hippocampal memories
Frontiers in Neuroscience, 2023 Although most neurons are generated embryonically, neurogenesis is maintained at low rates in specific brain areas throughout adulthood, including the dentate gyrus of the mammalian hippocampus.
Orsolya Fölsz +3 more
doaj +1 more source
Microelastic mapping of the rat dentate gyrus [PDF]
Royal Society Open Science, 2016 The lineage commitment of many cultured stem cells, including adult neural stem cells (NSCs), is strongly sensitive to the stiffness of the underlying extracellular matrix. However, it remains unclear how well the stiffness ranges explored in culture align with the microscale stiffness values stem cells actually encounter within their ...
Tomás Luque +3 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg +8 more
wiley +1 more source
Frontiers in Neuroscience, 2011 The dentate gyrus produces new granule neurons throughout adulthood in mammals from rodents to humans. During granule cell maturation, defined markers are expressed in a highly regulated sequential process, which is necessary for directed neuronal ...
Hideo eHagihara +9 more
doaj +1 more source
Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus. [PDF]
PLoS ONE, 2012 Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis.
Yvonne Imielski +12 more
doaj +1 more source
Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement
eLife, 2023 Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, little is known ...
Elijah A Petter +6 more
doaj +1 more source
The Mechanism of Rate Remapping in the Dentate Gyrus [PDF]
Neuron, 2010 Rate remapping is a recently revealed neural code in which sensory information modulates the firing rate of hippocampal place cells. The mechanism underlying rate remapping is unknown. Its characteristic modulation, however, must arise from the interaction of the two major inputs to the hippocampus, the medial entorhinal cortex (MEC), in which grid ...
Renno-Costa C. +2 more
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