Results 11 to 20 of about 111,284 (274)

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies) [PDF]

Progress in Brain Research, 2007
The dentate gyrus is a simple cortical region that is an integral portion of the larger functional brain system called the hippocampal formation. In this review, the fundamental neuroanatomical organization of the dentate gyrus is described, including principal cell types and their connectivity, and a summary of the major extrinsic inputs of the ...
Amaral David G, Scharfman Helen E, Lavenex Pierre   +2 more
openaire   +5 more sources

In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus

Journal of Pharmacological Sciences, 2013
Edaravone is clinically used in Japan for treatment of patients with acute cerebral infarction. To clarify the effect of edaravone on neurogenesis in the hippocampus following neuronal injury in the hippocampal dentate gyrus, we investigated the effect ...
Maho Kikuta, Tatsuo Shiba, Masanori Yoneyama, Koichi Kawada, Taro Yamaguchi, Eiichi Hinoi, Yukio Yoneda, Kiyokazu Ogita   +7 more
doaj   +1 more source

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. [PDF]

, 2018
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease.
A Fahrner, AD Workman, Antonio J. Gutierrez, Arantxa Cebrian-Silla, Arnold R. Kriegstein, Arturo Alvarez-Buylla, AS Hill, B Seri, B Steiner, C Wang, CV Dennis, Dashi Qi, David James, DR Kornack, DR Kornack, E Gould, E Gould, Edward F. Chang, Eric J. Huang, G Kempermann, Gary W. Mathern, GW Mathern, H Suh, H van Praag, H van Praag, HJ Kang, J Altman, J Altman, JE Malberg, JJ Breunig, Jose Manuel Garcia-Verdugo, Julia Chang, Kadellyn Sandoval, Kevin W. Kelley, KJ Mathews, KL Spalding, Kurtis I. Auguste, M Komitova, M Venere, Mercedes F. Paredes, MF Eckenhoff, Michael C. Oldham, N Patzke, N Sanai, P Yang, PS Eriksson, R Knoth, S Lugert, Shawn F. Sorrells, Simone Mayer, T Sugiyama, TE Bakken, Y Zhang, Zhengang Yang   +53 more
core   +1 more source

Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

Cell & Bioscience, 2019
Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +8 more
doaj   +1 more source

Status epilepticus induced Gadd45b is required for augmented dentate neurogenesis

Stem Cell Research, 2020
In animal models with temporal lobe epilepsy (TLE), the status epilepticus (SE) leads to a dramatic increase in number of newly born neuron in the subgranular zone (SGZ) of dentate gyrus.
Xin-Li Xiao, Xiao-Lin Wu, Peng-Bo Yang, Hai-Bo Hu, Yu Chen, Min-Li, Kai-Wei Si, Feng Wu, Jian-Xin Liu   +8 more
doaj   +1 more source

Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats [PDF]

, 2010
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells.
Asanuma, Masato, Doi, Maho, Gomita, Yutaka, Kawasaki, Hiromu, Kitamura, Yoshihisa, Matsunaga, Hisashi, Miyazaki, Ikuko, Nagamachi, Tomoko, Sendo, Toshiaki, Shinomiya, Kazuaki   +9 more
core   +1 more source

Beneficial In Vivo Effect of Aripiprazole on Neuronal Regeneration Following Neuronal Loss in the Dentate Gyrus: Evaluation Using a Mouse Model of Trimethyltin-Induced Neuronal Loss/Self-Repair in the Dentate Gyrus

Journal of Pharmacological Sciences, 2014
.: Aripiprazole is used clinically as an atypical antipsychotic. We evaluated the effect of in vivo treatment with aripiprazole on the proliferation and differentiation of neural stem/progenitor cells in a mouse model, trimethyltin-induced neuronal loss ...
Masanori Yoneyama, Shigeru Hasebe, Noriko Kawamoto, Tatsuo Shiba, Taro Yamaguchi, Maho Kikuta, Makoto Shuto, Kiyokazu Ogita   +7 more
doaj   +1 more source

Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. [PDF]

PLoS Computational Biology, 2014
Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial ...
Julian Tejada, Norberto Garcia-Cairasco, Antonio C Roque   +2 more
doaj   +1 more source

Decrease in glucose transporter 1 levels and translocation of glucose transporter 3 in the dentate gyrus of C57BL/6 mice and gerbils with aging

Laboratory Animal Research, 2018
In the present study, we compared the cell-specific expression and changes protein levels in the glucose transporters (GLUTs) 1 and 3, the major GLUTs in the mouse and gerbil brains using immuno-histochemistry and Western blot analysis. In both mouse and
Kwon Young Lee, Dae Young Yoo, Hyo Young Jung, Loktam Baek, Hangyul Lee, Hyun Jung Kwon, Jin Young Chung, Seok Hoon Kang, Dae Won Kim, In Koo Hwang, Jung Hoon Choi   +10 more
doaj   +1 more source

Dentate gyrus formation requires Emx2 [PDF]

Development, 1996
ABSTRACT Emx 1 and 2 are the murine homologues of the Drosophila empty spiracles gene and based on their expression pattern may be involved in the regional specification of the mammalian forebrain. During early embryogenesis, Emx2 is expressed in the presumptive cerebral cortex and olfactory bulbs and later, in the hippocampus proper and
PELLEGRINI, Massimo, A. Mansouri, A. Simeone, E. Boncinelli, P. Gruss   +4 more
openaire   +4 more sources