Results 41 to 50 of about 72,047 (256)

Sex steroids and the dentate gyrus [PDF]

, 2007
In the late 1980s, the finding that the dentate gyrus contains more granule cells in the male than in the female of certain mouse strains provided the first indication that the dentate gyrus is a significant target for the effects of sex steroids during development. Gonadal hormones also play a crucial role in shaping the function and morphology of the
Tibor, Hajszan, Teresa A, Milner, Csaba, Leranth   +2 more
openaire   +2 more sources

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

Expression of the AMPA receptor subunits GluR1 and GluR2 is associated with granule cell maturation in the dentate gyrus

Frontiers in Neuroscience, 2011
The dentate gyrus produces new granule neurons throughout adulthood in mammals from rodents to humans. During granule cell maturation, defined markers are expressed in a highly regulated sequential process, which is necessary for directed neuronal ...
Hideo eHagihara, Hideo eHagihara, Koji eOhira, Koji eOhira, Keiko eToyama, Keiko eToyama, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa   +9 more
doaj   +1 more source

Synaptic Plasticity in the Human Dentate Gyrus [PDF]

The Journal of Neuroscience, 2000
Activity-dependent plasticity is a fundamental feature of most CNS synapses and is thought to be a synaptic correlate of memory in rodents. In humans, NMDA receptors have been linked to verbal memory processes, but it is unclear whether NMDA receptor-dependent synaptic plasticity can be recruited for information storage in the human CNS.
H, Beck, I V, Goussakov, A, Lie, C, Helmstaedter, C E, Elger   +4 more
openaire   +2 more sources

Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

eLife, 2023
Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, little is known ...
Elijah A Petter, Isabella P Fallon, Ryan N Hughes, Glenn DR Watson, Warren H Meck, Francesco Paolo Ulloa Severino, Henry H Yin   +6 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Dentate gyrus and spatial behaviour

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009
This article reviews evidence from studies employing colchicine-induced granule cell loss in the adult rat brain, and irradiation-induced hypoplasia of the neonatal dentate gyrus, on the performance of spatial and non-spatial behavioral tasks. The general picture emerging from this analysis reveals that the dentate gyrus granule cells are critically ...
Gilberto Fernando, Xavier, Valéria Catelli Infantozzi, Costa   +1 more
openaire   +2 more sources

Nonrandom Local Circuits in the Dentate Gyrus [PDF]

The Journal of Neuroscience, 2008
The dentate hilus has been extensively studied in relation to its potential role in memory and in temporal lobe epilepsy. Little is known, however, about the synapses formed between the two major cell types in this region, glutamatergic mossy cells and hilar interneurons, or the organization of local circuits involving these cells.
Phillip, Larimer, Ben W, Strowbridge
openaire   +2 more sources

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Computational Pattern Separation Models of Dentate Gyrus Neural Subpopulation in the Hippocampus

Caspian Journal of Neurological Sciences, 2022
Hippocampus is a part of the brain that has an essential role in memory and learning. It is involved in many cognitive and behavioral phenomena, including the pattern separation process: the ability to distinguish patterns with very high similarity.
Nazal Modhej, Azam Bastanfard, Mohammad Teshnehlab, Somayeh Raiesdana   +3 more
doaj