Results 81 to 90 of about 62,950 (262)

Proteomic Profiling of the Epileptic Dentate Gyrus

Brain Pathology, 2010
AbstractThe development of epilepsy is often associated with marked changes in central nervous system cell structure and function. Along these lines, reactive gliosis and granule cell axonal sprouting within the dentate gyrus of the hippocampus are commonly observed in individuals with temporal lobe epilepsy (TLE). Here we used the pilocarpine model of
Aiqing, Li, Yun-Sik, Choi, Heather, Dziema, Ruifeng, Cao, Hee-Yeon, Cho, Yeon Joo, Jung, Karl, Obrietan   +6 more
openaire   +3 more sources

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus

Stem Cell Reports, 2019
Summary: EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of ...
Pei-Pei Liu, Ya-Jie Xu, Shang-Kun Dai, Hong-Zhen Du, Ying-Ying Wang, Xing-Guo Li, Zhao-Qian Teng, Chang-Mei Liu   +7 more
doaj   +1 more source

Paroxysmal slow waves mark ictal networks

Epilepsia, EarlyView.
Abstract Objective Epilepsy diagnosis and treatment monitoring are hindered by the episodic, heterogeneous expression of seizures and by normal‐appearing scalp electroencephalography (EEG) in many patients. We previously described paroxysmal slow‐wave events (PSWEs), brief epochs of broadband slowing detectable on EEG in people with epilepsy.
Florent J. M. Boyer‐Aymé, Hamza Imtiaz, Ofer Prager, Evyatar Swissa, Alaa Abu Ahmad, Yonatan Serlin, Refat Aboghazleh, Ilan Goldberg, Maayan Ben nun Caller, Idit Tamir, Oded Shor, Ben Whatley, Felix Benninger, Alon Friedman   +13 more
wiley   +1 more source

Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats

Neuroscience Insights, 2020
Background: Traumatic brain injury is a significant public health issue that results in serious disability in survivors. Traumatic brain injury patients are often intoxicated with alcohol when admitted to the hospital; however, it is not clear how acute ...
Son T Ton, Natalie S Adamczyk, Jack P Gerling, Ian C Vaagenes, Joanna Y Wu, Kevin Hsu, Timothy E O’Brien, Shih-Yen Tsai, Gwendolyn L Kartje   +8 more
doaj   +1 more source

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy

Epilepsia, EarlyView.
Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger, Xinbing Zhang, Thomas Lisko, Hafsa Farooqi, Steffen Ventz, Sandipan Pati, Thomas R. Henry, David P. Darrow, Michael C. Park, Theoden I. Netoff, Robert A. McGovern   +10 more
wiley   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Toward a full-scale computational model of the rat dentate gyrus

Frontiers in Neural Circuits, 2012
Recent advances in parallel computing, including the creation of the parallel version of the NEURON simulation environment, have allowed for a previously unattainable level of complexity and detail in neural network models.
Calvin James Schneider, Marianne eBezaire, Ivan eSoltesz   +2 more
doaj   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

Effect of interaventricular injection of Vitamin C on the histological structural of dentate gyrus of hipocampus in epileptic rats

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Hippocampus is the main region in cortex of the brain that involved in epilepsy. This study was done to determine the effect of intraventricular injection of vitamin C on histological structure of dentate gyrus of hipocampus in ...
R Golmohammadi, B Kmalimansh
doaj