Results 81 to 90 of about 76,364 (261)

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

Nature Communications
The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context,
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang, Marlene Bartos   +3 more
doaj   +1 more source

Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus-Dentate Gyrus Circuit. [PDF]

CNS Neurosci Ther
Electroacupuncture at ST36 alleviates cognitive deficits and restores hippocampal synaptic plasticity in VCI rats by activating the SuMGlu‐DG circuit. This study identifies the SuMGlu‐DG circuit as an essential mediator for the therapeutic and neuroprotective effects of acupuncture in vascular‐induced cognitive decline.
Wan F, Wang L, Wang QY, Yang JW, Liu CZ.
europepmc   +2 more sources

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

Differential properties of dentate gyrus and CA1 neural precursors.

, 2004
International audienceIn the present article we investigated the properties of CA1 and dentate gyrus cell precursors in adult rodents both in vivo and in vitro.
S. Weiss, A. Represa, Weiss, S., I. Jorquera, Represa, Alfonso, H. Becq, Y. Ben-Ari, Jorquera, Isabel, Becq, Hélène, Ben-Ari, Yehezkel   +9 more
core   +1 more source

Paroxysmal slow waves mark ictal networks

Epilepsia, EarlyView.
Abstract Objective Epilepsy diagnosis and treatment monitoring are hindered by the episodic, heterogeneous expression of seizures and by normal‐appearing scalp electroencephalography (EEG) in many patients. We previously described paroxysmal slow‐wave events (PSWEs), brief epochs of broadband slowing detectable on EEG in people with epilepsy.
Florent J. M. Boyer‐Aymé, Hamza Imtiaz, Ofer Prager, Evyatar Swissa, Alaa Abu Ahmad, Yonatan Serlin, Refat Aboghazleh, Ilan Goldberg, Maayan Ben nun Caller, Idit Tamir, Oded Shor, Ben Whatley, Felix Benninger, Alon Friedman   +13 more
wiley   +1 more source

Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus

Stem Cell Reports, 2019
Summary: EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of ...
Pei-Pei Liu, Ya-Jie Xu, Shang-Kun Dai, Hong-Zhen Du, Ying-Ying Wang, Xing-Guo Li, Zhao-Qian Teng, Chang-Mei Liu   +7 more
doaj   +1 more source

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy

Epilepsia, EarlyView.
Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger, Xinbing Zhang, Thomas Lisko, Hafsa Farooqi, Steffen Ventz, Sandipan Pati, Thomas R. Henry, David P. Darrow, Michael C. Park, Theoden I. Netoff, Robert A. McGovern   +10 more
wiley   +1 more source

Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats

Neuroscience Insights, 2020
Background: Traumatic brain injury is a significant public health issue that results in serious disability in survivors. Traumatic brain injury patients are often intoxicated with alcohol when admitted to the hospital; however, it is not clear how acute ...
Son T Ton, Natalie S Adamczyk, Jack P Gerling, Ian C Vaagenes, Joanna Y Wu, Kevin Hsu, Timothy E O’Brien, Shih-Yen Tsai, Gwendolyn L Kartje   +8 more
doaj   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Dentate gyrus is needed for memory retrieval.

The hippocampus is crucial for acquiring and retrieving episodic and contextual memories. In previous studies, the inactivation of dentate gyrus (DG) neurons by chemogenetic- and optogenetic-mediated hyperpolarization led to opposing conclusions about DG'
Dogbevia, GK, Hasan, MT, Carretero-Guillén, Alejandro, Larkum, ME, Gómez Climent, María Ángeles, Sprengel, R, Vlachos, A, Bertocchi, I, Delgado-García, JM, Treviño, M, Gruart, A   +10 more
core   +3 more sources