Results 81 to 90 of about 111,284 (274)
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
ASN Neuro, 2019 There is growing evidence from epidemiological studies that especially midlife physical activity might exert a positive influence on the risk and progression of Alzheimer’s disease.
Anna-Lina Gerberding +4 more
doaj +1 more source
F1000Research, 2018 Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus.
Daniel A. Berg +3 more
doaj +1 more source
The effect of Urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats [PDF]
, 2009 Diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. These alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis.
Afshar, M. +2 more
core
A receptor-based analysis of local ecosystems in the human brain. [PDF]
, 2017 BackgroundAs a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but the similarity of their functional ...
Janušonis, Skirmantas
core +1 more source
Evolution of the mammalian dentate gyrus [PDF]
Journal of Comparative Neurology, 2015 ABSTRACTThe dentate gyrus (DG), a part of the hippocampal formation, has important functions in learning, memory, and adult neurogenesis. Compared with homologous areas in sauropsids (birds and reptiles), the mammalian DG is larger and exhibits qualitatively different phenotypes: 1) folded (C‐ or V‐shaped) granule neuron layer, concave toward the hilus
openaire +2 more sources
Advanced Science, EarlyView.This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou +7 more
wiley +1 more source
Hemisphere-specific spatial representation by hippocampal granule cells
Nature Communications, 2022 Lateralization of hippocampal function has been observed in CA1-3, but the extent to which there is lateralization in the dentate gyrus is less clear. Using 2-photon calcium imaging of granule cells over five days in mice, the authors explore differences
Thibault Cholvin, Marlene Bartos
doaj +1 more source
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott +15 more
wiley +1 more source