Results 81 to 90 of about 72,047 (256)

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat

BMC Neuroscience, 2007
Background The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model ...
Ferraro Giuseppe, Sardo Pierangelo
doaj   +1 more source

Proteomic Profiling of the Epileptic Dentate Gyrus

Brain Pathology, 2010
AbstractThe development of epilepsy is often associated with marked changes in central nervous system cell structure and function. Along these lines, reactive gliosis and granule cell axonal sprouting within the dentate gyrus of the hippocampus are commonly observed in individuals with temporal lobe epilepsy (TLE). Here we used the pilocarpine model of
Aiqing, Li, Yun-Sik, Choi, Heather, Dziema, Ruifeng, Cao, Hee-Yeon, Cho, Yeon Joo, Jung, Karl, Obrietan   +6 more
openaire   +3 more sources

Microelastic mapping of the rat dentate gyrus [PDF]

Royal Society Open Science, 2016
The lineage commitment of many cultured stem cells, including adult neural stem cells (NSCs), is strongly sensitive to the stiffness of the underlying extracellular matrix. However, it remains unclear how well the stiffness ranges explored in culture align with the microscale stiffness values stem cells actually encounter within their ...
Tomás Luque, Michael S. Kang, David V. Schaffer, Sanjay Kumar   +3 more
openaire   +3 more sources

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

The Mechanism of Rate Remapping in the Dentate Gyrus [PDF]

Neuron, 2010
Rate remapping is a recently revealed neural code in which sensory information modulates the firing rate of hippocampal place cells. The mechanism underlying rate remapping is unknown. Its characteristic modulation, however, must arise from the interaction of the two major inputs to the hippocampus, the medial entorhinal cortex (MEC), in which grid ...
Renno-Costa C., Lisman J.E., Verschure P.F.M.J.   +2 more
openaire   +2 more sources

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats.

PLoS ONE, 2015
Estradiol increases cell proliferation in the dentate gyrus of the female rodent but it is not known whether the G protein-coupled estrogen receptor (GPER), a membrane receptor, is involved in this process, nor whether there are regional differences in ...
Paula Duarte-Guterman, Stephanie E Lieblich, Carmen Chow, Liisa A M Galea   +3 more
doaj   +1 more source

Remifentanil alleviates transient cerebral ischemia-induced memory impairment through suppression of apoptotic neuronal cell death in gerbils [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundDuring neurosurgical procedures, patients are often exposed to hypoxic and ischemic brain damage. Cerebral ischemia leads to neuronal cell death and eventually causes neurological impairments.
Sung-Wook Park, Jae-Woo Yi, Young-Min Kim, Jong-Man Kang, Dong Ok Kim, Mal-Soon Shin, Chang-Ju Kim, Doo Ik Lee, Dong-Hee Kim, Bong Jae Lee   +9 more
doaj   +1 more source

Differential properties of dentate gyrus and CA1 neural precursors.

, 2004
International audienceIn the present article we investigated the properties of CA1 and dentate gyrus cell precursors in adult rodents both in vivo and in vitro.
S. Weiss, A. Represa, Weiss, S., I. Jorquera, Represa, Alfonso, H. Becq, Y. Ben-Ari, Jorquera, Isabel, Becq, Hélène, Ben-Ari, Yehezkel   +9 more
core   +1 more source