Results 121 to 130 of about 72,047 (256)
Model.The repository constains the datasets and computational models code used in the publication: Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing Dentate Gyrus functionality.Peer ...
Canals, Santiago
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Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
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Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
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Reassessing pattern separation in the dentate gyrus [PDF]
Frontiers in Behavioral Neuroscience, 2013 The dentate gyrus (DG) is postulated to be a “pattern separator” (Marr, 1971; Rolls, 1989a,b, 1990; Treves and Rolls, 1994). Yet, the definition of pattern separation has become a haze, with researchers using the term interchangeably to describe computational processes, changes in cell ensemble activity, and even behavioral phenomena (Leutgeb et al ...
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Neuroanatomical and functional correlates in borderline personality disorder: A narrative review
Ibrain, Volume 11, Issue 1, Page 19-31, Spring 2025.Borderline personality disorder (BPD) is considered a dysfunctional, stable, and pervasive alteration in personality functioning with the inability to adapt to the environment, mental rigidity, and ego‐syntonic, and like all personality disorders is a consistent pattern of inner experience and behavior that deviates markedly from the expectations of ...
Giulio Perrotta
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Clozapine Prevents a Decrease in Neurogenesis in Mice Repeatedly Treated With Phencyclidine
Journal of Pharmacological Sciences, 2007 It has recently been suggested that neurogenesis in the dentate gyrus is decreased in schizophrenia and this phenomenon may contribute to the pathogenesis of the disorder.
Kenji Maeda +7 more
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, 2013 A. Dentate gyrus of a normal mouse. B. Dentate gyrus of a pilocarpine-treated mouse that survived status epilepticus (SE) showing mossy fiber sprouting. A1 and B1 are enlarged boxed regions of A and B.
Bret N. Smith (364701) +1 more
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Interdisciplinary Medicine, EarlyView.Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang +22 more
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Structural plasticity in the dentate gyrus- revisiting a classic injury model.
Frontiers in Neural Circuits, 2013 The adult brain is in a continuous state of remodeling. This is nowhere more true than in the dentate gyrus, where competing forces such as neurodegeneration and neurogenesis dynamically modify neuronal connectivity, and can occur simultaneously.
Julia V. Perederiy, Gary L. Westbrook
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Elevated levels of various proteins in MEC and in dentate gyrus of MPS IIIA brain.
, 2013 Staining was performed with antibodies against the proteins shown in a 7 months-old MPS IIIA mouse brain. The first 3 rows are for the MEC region and the bottom row for dentate gyrus.
Hui-Zhi Zhao (340007) +2 more
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