Results 121 to 130 of about 76,364 (261)
From adult dentate gyrus neurogenesis to pattern separation
, 2019 For a few decades, adult dentate gyrus neurogenesis has been widely recognized by the neuroscience community as an intriguing phenomenon. Two observations are particularly puzzling.
Gozel, Olivia
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Associations between TMEM106B C‐terminal fragment aggregation, age, and TDP‐43 or tau pathology
Brain Pathology, EarlyView.TMEM106B C‐terminal fragment (CTF) aggregation represents an age‐associated, common, diffuse phenomenon emerging after midlife with a weak association with TDP‐43 or tau pathology. These findings suggest that TMEM106B fibrillization may define a distinct axis of protein aggregation in the aging human brain. Abstract Transmembrane protein 106B (TMEM106B)
Albert Acewicz +5 more
wiley +1 more source
Human brain matters: Navigating the neuropathology of COVID‐19
Brain Pathology, EarlyView.Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland +4 more
wiley +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Development of phasic and tonic inhibitory GABAergic currents in mouse dentate gyrus
, 2008 The present thesis describes functional and morphological properties of interneurons and granule cell in developing mouse dentate gyrus, with special focus on inhibitory GABAergic currents.
Holter, Nadine
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British Journal of Pharmacology, EarlyView.Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues +8 more
wiley +1 more source
, 2010 The dentate gyrus is one of only two regions of the mammalian brain where substantial neurogenesis occurs postnatally. However, detailed quantitative information about the postnatal structural maturation of the primate dentate gyrus is meager.
Banta Lavenex, Pamela A. +7 more
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British Journal of Pharmacology, EarlyView.Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu +9 more
wiley +1 more source
Encoding Spatial Context: A Hypothesis on the Function of the
, 2008 There is now a very extensive body of data on the spatial correlates of neural activity in the hippocampal system of rodents. Place-specific activity is found throughout the system and lesions of various hippocampal regions cause severe deficits on ...
Dentate Gyrus-hilus System
core
SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism
Cell Proliferation, EarlyView.This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang +5 more
wiley +1 more source