Multimodal Imaging Investigation of the Dentato‐Thalamo‐Cortical Pathway in Friedreich's Ataxia
Movement Disorders, EarlyView.Abstract Background Friedreich's ataxia (FRDA) is a spinocerebellar neurodegenerative disorder. The dentato‐thalamo‐cortical (DTC) pathway, an important cerebellar output involved in motor control, plays a crucial role in the neural mechanisms underlying ataxia symptoms in FRDA.
Yinghua Jing +22 more
wiley +1 more source
Network structure determines patterns of network reorganization during adult neurogenesis [PDF]
, 2009 New cells are generated throughout life and integrate into the hippocampus via the process of adult neurogenesis. Epileptogenic brain injury induces many structural changes in the hippocampus, including the death of interneurons and altered connectivity ...
Ben-Jacob, Eshel +4 more
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Born to Be Wild: A Case for Targeting Ectopic Adult Born Granule Cells for Seizure Control. [PDF]
, 2020 [Box: see text]
Corrubia, Lucas, Santhakumar, Viji
core
Reassessing pattern separation in the dentate gyrus [PDF]
Frontiers in Behavioral Neuroscience, 2013 The dentate gyrus (DG) is postulated to be a “pattern separator” (Marr, 1971; Rolls, 1989a,b, 1990; Treves and Rolls, 1994). Yet, the definition of pattern separation has become a haze, with researchers using the term interchangeably to describe computational processes, changes in cell ensemble activity, and even behavioral phenomena (Leutgeb et al ...
Adam eSantoro
openalex +4 more sources
Movement Disorders, EarlyView.Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda +9 more
wiley +1 more source
Transcription and DNA methylation signatures of paternal behavior in hippocampal dentate gyrus of prairie voles [PDF]
, 2023 Nicholas J. Waddell +5 more
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Medicine Advances, EarlyView.Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting +1 more
wiley +1 more source
Human neuronal stargazin-like proteins, gamma(2), gamma(3) and gamma(4); an investigation of their specific localization in human brain and their influence on Ca(V)2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]
, 2003 Background: Stargazin (gamma(2)) and the closely related gamma(3), and gamma(4) transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) gamma subunits and transmembrane alpha-amino-3 ...
Clare, JJ, Dolphin, AC, Moss, FJ
core
Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models
VIEW, EarlyView.Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley +1 more source