Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices. [PDF]
Shu WC, Jackson MB.
europepmc +1 more source
Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar +8 more
wiley +1 more source
CaMKII Neurons in the Dentate Gyrus Are Involved in Regulating Cognitive Impairment in Mice Induced by Stress Caused by Violence. [PDF]
Shao G +7 more
europepmc +1 more source
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek +5 more
wiley +1 more source
Impaired WNT3/IGF-1 Signaling in Dorsal Dentate Gyrus Contributes to Chronic Pain-Related Cognitive Impairment. [PDF]
An Y +8 more
europepmc +1 more source
A novel mouse model of mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) by unilateral, partial ablation of hippocampal GABAergic neurons is established. The model recapitulates key features of the human condition, including spontaneous recurrent seizures, HS‐like pathology, and associated cognitive deficits.
Ting Tang +10 more
wiley +1 more source
Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory. [PDF]
Wilmerding LK +4 more
europepmc +1 more source
Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability
Astrocytic TCF7L2 impacts extracellular glutamate and glutamine levels. Loss of astrocytic TCF7L2 disrupts extracellular potassium clearance. TCF7L2‐dependent astrocytic changes reduce neuronal excitability. ABSTRACT Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal ...
Mariusz Popek +10 more
wiley +1 more source
Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype. [PDF]
Shoji H +6 more
europepmc +1 more source

