Results 31 to 40 of about 139,984 (307)

Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation

Stem Cell Reports, 2019
Summary: Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved.
Odette Leiter, Suse Seidemann, Rupert W. Overall, Beáta Ramasz, Nicole Rund, Sonja Schallenberg, Tatyana Grinenko, Ben Wielockx, Gerd Kempermann, Tara L. Walker   +9 more
doaj   +1 more source

Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

Nature Communications, 2018
Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus.
Tie-Yuan Zhang, C. Keown, Xianglan Wen, Junhao Li, D. Vousden, C. Anacker, Urvashi Bhattacharyya, R. Ryan, J. Diorio, Nicholas O’Toole, J. Lerch, E. Mukamel, M. Meaney   +12 more
semanticscholar   +1 more source

Contribution of Egr1/Zif268 to activity-dependent Arc/Arg3.1 transcription in the dentate gyrus and area CA1 of the hippocampus

Frontiers in Behavioral Neuroscience, 2011
Egr1, a member of the Egr family of transcription factors, and Arc are immediate early genes known to play major roles in synaptic plasticity and memory.
Zsuzsa ePenke, Zsuzsa ePenke, Carine eChagneau, Carine eChagneau, Serge eLaroche, Serge eLaroche   +5 more
doaj   +1 more source

Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine

Molecular Psychiatry, 2018
Depression is a leading cause of disability. Current pharmacological treatment of depression is insufficient, and development of improved treatments especially for treatment-resistant depression is desired.
T. Shuto, M. Kuroiwa, N. Sotogaku, Y. Kawahara, Y. Oh, Jin-Hyeok Jang, Chang-Hoon Shin, Y. Ohnishi, Yuuki Hanada, T. Miyakawa, Yong Kim, P. Greengard, A. Nishi   +12 more
semanticscholar   +1 more source

The dentate gyrus in depression

European Journal of Neuroscience, 2019
Extensive preclinical research has been conducted in recent years to reveal the cell types, neuronal circuits and molecular and morphological changes implicated in the function of the dentate gyrus in depression.
G. Umschweif, P. Greengard, Y. Sagi
semanticscholar   +1 more source

Rapid stimulation of human dentate gyrus function with acute mild exercise

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Our previous work has shown that mild physical exercise can promote better memory in rodents. Here, we use functional MRI in healthy young adults to assess the immediate impact of a short bout of mild exercise on the brain mechanisms ...
Kazuya Suwabe, Kyeongho Byun, Kazuki Hyodo, Zachariah M. Reagh, Jared M. Roberts, A. Matsushita, K. Saotome, Genta Ochi, Takemune Fukuie, Kenji Suzuki, Y. Sankai, M. Yassa, H. Soya   +12 more
semanticscholar   +1 more source

p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise

Frontiers in Cellular Neuroscience, 2019
In the neurogenic niches—the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles—stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus ...
Laura Micheli, Giorgio D’Andrea, Giorgio D’Andrea, Manuela Ceccarelli, Alessandra Ferri, Raffaella Scardigli, Felice Tirone   +6 more
doaj   +1 more source

Capicua regulates the development of adult-born neurons in the hippocampus

Scientific Reports, 2021
New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation.
Brenna Hourigan, Spencer D. Balay, Graydon Yee, Saloni Sharma, Qiumin Tan   +4 more
doaj   +1 more source

Adult-born neurons add flexibility to hippocampal memories

Frontiers in Neuroscience, 2023
Although most neurons are generated embryonically, neurogenesis is maintained at low rates in specific brain areas throughout adulthood, including the dentate gyrus of the mammalian hippocampus.
Orsolya Fölsz, Orsolya Fölsz, Stéphanie Trouche, Vincent Croset   +3 more
doaj   +1 more source

Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive

Nature Network Boston, 2018
Major depressive disorder (MDD) is considered a ‘circuitopathy’, and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction.
S. Yun, Ryan P. Reynolds, I. Petrof, Alicia White, P. D. Rivera, Amir Segev, Adam D. Gibson, Maiko Suarez, Matthew J. DeSalle, Naoki Ito, S. Mukherjee, Devon R. Richardson, Catherine E. Kang, Rebecca C. Ahrens-Nicklas, I. Soler, D. Chetkovich, S. Kourrich, D. Coulter, A. Eisch   +18 more
semanticscholar   +1 more source