Results 151 to 160 of about 54,854 (258)

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Human Deoxycytidine Kinase

Journal of Biological Chemistry, 1989
S H Huang, J M Tomich, H Wu, A Jong, J Holcenberg   +4 more
openaire   +1 more source

A Novel Modified Bu/Vp16/cy/Flu/Ara‐C Conditioning Regimen Enhances Outcomes for High‐Risk Acute Lymphoblastic Leukemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Purpose Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) effectively treats high‐risk acute lymphoblastic leukemia (ALL), yet challenges persist due to post‐transplant relapse and conditioning regimen toxicities. The determination of an appropriate preconditioning regimen is critical to improving patient outcomes.
Xiaoyan Zhao, Yifan Yao, Yan Sun, Ziwei Xu, Aiguo Liu, Xin Dong, Huafang Wang   +6 more
wiley   +1 more source

Altered DNA Methyltransferase Expression in Pulmonary Large‐Cell Neuroendocrine Carcinoma: Pilot Experimental Data Targeted DNMT1, DNMT3A, and DNMT3B

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Introduction Large cell neuroendocrine carcinoma (LCNEC) is a subtype of non‐small‐cell lung carcinoma with poorly understood methylation characteristics, including the activity of DNA methyltransferases. Despite the pivotal role of DNA methyltransferases in epigenetic regulation, their expression profile in LCNEC remains unexplored.
Adam Put, Katerina Smesny Trtkova, Marcel Mittak, Petra Herentinova, Jana Vaculova, Radoslava Cernekova, Jozef Skarda   +6 more
wiley   +1 more source

Nanopipette–DNA‐Nanopore Hybrid System for Small Molecule Detection

ChemPlusChem, Volume 91, Issue 3, March 2026.
A hybrid nanopore composed of an aptamer‐modified DNA origami nanopore and a glass nanopipette for adenosine triphosphate (ATP) detection is developed. This article shows the applicability of the hybrid nanopore for small molecule detection by classifying ion current signals and revealing the difference in the ratio of open/close signals in the absence
Hiromu Akai, Kan Shoji
wiley   +1 more source

Effect of Renal Impairment on the Pharmacokinetics and Safety of Doxecitine and Doxribtimine: A Single-Dose Phase 1 Study. [PDF]

Clin Pharmacol Drug Dev
Mittur A, VanMeter SA.
europepmc   +1 more source

Alginate Oligosaccharides Attenuate Ochratoxin A‐Induced Liver Injury through Regulating the Interaction of Nrf2 and NF‐κB Signaling Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao, Xueqing Ye, Yan Guo, Zhongxiang Zhao, Qinghua Yao, Yaoyao Wang, Huimei Liu, Ziwei Lin, Wenchao Liu   +8 more
wiley   +1 more source

Cladribine Preserves Normal Central Nervous System Cellular Activity and Promotes Neuroprotection to Oxidative Stress Damage. [PDF]

Int J Mol Sci
Eixarch H, Calvo-Barreiro L, Fissolo N, Boschert U, Hervera A, Comabella M, Montalban X, Espejo C.   +7 more
europepmc   +1 more source

Deoxycytidine kinase (DCK) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets

Food Frontiers, Volume 7, Issue 2, March 2026.
After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao, Xinyi Tian, YiKun Li, Jie Zhang, Hongcan Huang, Yu‐Xuan Lyu, Baichuan Deng   +6 more
wiley   +1 more source