Results 91 to 100 of about 14,531 (182)

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis

The Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY In plants, nucleotide de novo synthesis is required throughout development to provide building blocks for the synthesis of DNA, RNA and nucleotide‐derived cofactors. Inosine Monophosphate Dehydrogenases (IMPDH) are key enzymes in de novo guanylate synthesis.
Eva Dörfer, Zahra Sadeghi, Vincent Frick, Katharina Ebel, Adrian Heide, Tom Niehoff, Susanne Zehner, Lisa Fischer, Claus‐Peter Witte, Marco Herde, Torsten Möhlmann   +10 more
wiley   +1 more source

A clinical case in pediatric practice: mitochondrial DNA depletion syndrome, type 2 (myopathic form)

Якутский медицинский журнал
The paper discusses the diagnosis and treatment of mitochondrial DNA depletion syndrome (MDS), which is associated with a defect in the thymidine kinase 2 (TK2) gene.
A. V. Batyarkina, B. S. Roy, N. A. Dorokhov, D. G. Polukhin, D. V. Osintsev, D. O. Akhmetzhanova   +5 more
doaj   +1 more source

Deoxycytidine Kinase

Journal of Biological Chemistry, 1969
JOHN P. DURHAM, DAVID H. IVES
openaire   +1 more source

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

Cell Reports
Summary: Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements.
Amir Hosseini, Håvard T. Lindholm, Raymond Chen, Parinaz Mehdipour, Sajid A. Marhon, Charles A. Ishak, Paul C. Moore, Marie Classon, Andrea Di Gioacchino, Benjamin Greenbaum, Daniel D. De Carvalho   +10 more
doaj   +1 more source

Human equilibrative nucleoside transporter-1 and deoxycytidine kinase can predict gemcitabine effectiveness in Egyptian patients with Hepatocellular carcinoma. [PDF]

J Clin Lab Anal, 2020
Attia F, Fathy S, Anani M, Hassan A, Attia F, Ibrahim G, Elazab M.   +6 more
europepmc   +1 more source

Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase. [PDF]

Mol Cancer Ther, 2020
Vena F, Bayle S, Nieto A, Quereda V, Aceti M, Frydman SM, Sansil SS, Grant W, Monastyrskyi A, McDonald P, Roush WR, Teng M, Duckett D.   +12 more
europepmc   +1 more source

Deoxycytidine Kinase [PDF]

, 2020
openaire   +1 more source

Gene expression of hENT1, dCK, CDA, dCMPD and topoisomerase IIα as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin

Cancer Management and Research, 2018
Bibi Kulsoom,1,2 Tahir Sultan Shamsi,1 Nasir Ali Afsar3 1Center of Excellence in Molecular Medicine, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan; 2Department of Biochemistry, Jinnah Medical and Dental College ...
Kulsoom B, Shamsi TS, Afsar NA
doaj  

HSP90 regulates dCK stability and inhibits ionizing radiation-induced ferroptosis in cervical cancer cells

Cell Death Discovery
Cervical squamous cell carcinoma (CESC) is one of the most common cancers in women, and radiotherapy has been used as a primary treatment. However, its efficacy is limited by intrinsic and acquired radiation resistance.
Yue Wang, Huilin Ji, Tianpeng Yang, Yi Liu, Xiang He, Xinyue Jiang, Zipeng Lu, Liu Han, Xiaodong Liu, Shumei Ma   +9 more
doaj   +1 more source