Results 111 to 120 of about 507,870 (221)

The Inhibition of Human Deoxycytidine Kinase Mutants by Deoxycytidine Triphosphate

, 2014
Deoxycytidine kinase (dCK) is responsible for catalyzing the phosphorylation of nucleosides to monophosphate forms within the nucleoside salvage pathway by using nucleotide triphosphates ATP or UTP as a phosphoryl donor.
Reese, Loriann Noelle
core  

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase

, 2010
Gemcitabine, a deoxycytidine analog, active against non-small cell lung cancer, is phosphorylated by deoxycytidine kinase (dCK) to active nucleotides.
Bergman, Andries M., Sigmond, Jennifer, Hoebe, Eveline K., Loves, W.J.P., Peters, G.J., Peters, Godefridus J., Leon, Leticia G., Hoebe, E.K., Sigmond, J., Leon, L.G., Loves, Willem J. P., Bergman, A.M.   +11 more
core   +1 more source

A clinical case in pediatric practice: mitochondrial DNA depletion syndrome, type 2 (myopathic form)

Якутский медицинский журнал
The paper discusses the diagnosis and treatment of mitochondrial DNA depletion syndrome (MDS), which is associated with a defect in the thymidine kinase 2 (TK2) gene.
A. V. Batyarkina, B. S. Roy, N. A. Dorokhov, D. G. Polukhin, D. V. Osintsev, D. O. Akhmetzhanova   +5 more
doaj   +1 more source

Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Schematic overview of the pathways and pathological mechanisms connecting atmospheric aerosol exposure to PD. Atmospheric aerosols, including PM2.5 and nanometer/ultrafine particles loaded with metal particles, persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and dioxins, enter the body predominantly via pulmonary ...
Yitian Gao, Minxiang Dong, Chenyang Duan, Xiaohan Zheng, Liming Qu   +4 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

An NMR conformational study of the complexes of C-13/H-2 double-labelled 2 '-deoxynucleosides and deoxycytidine kinase (dCK)

, 2000
The structures of the bound C-13/H-2 double-labelled [(2' R/S,5' R/S)-H-2(2)-1',2',3',4',5'-C-13(5)]-2'-deoxyadenosine (dAdo) and the corresponding 2'-deoxycytidine (dCyd) moieties in the complexes with human recombinant deoxycytidine kinase (dCK) have ...
Usova, E, Chattopadhayaya, J, Milecki, J, Maltseva, T,, Foldesi, A, Eriksson, A   +5 more
core  

Structural and Kinetic Characterization of Human Deoxycytidine Kinase Variants Able To Phosphorylate 5-Substituted Deoxycytidine and Thymidine Analogues,

, 2016
The physiological role of human deoxycytidine kinase (dCK) is to phosphorylate deoxynucleosides required for DNA synthesis, with the exception of thymidine.
Saugata Hazra (1322079), Stephan Ort (1350795), Arnon Lavie (307968), Manfred Konrad (361313)   +3 more
core   +1 more source

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

Cell Reports
Summary: Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements.
Amir Hosseini, Håvard T. Lindholm, Raymond Chen, Parinaz Mehdipour, Sajid A. Marhon, Charles A. Ishak, Paul C. Moore, Marie Classon, Andrea Di Gioacchino, Benjamin Greenbaum, Daniel D. De Carvalho   +10 more
doaj   +1 more source

DUSP12 Regulates NAT10‐Mediated RNA Acetylation to Modulate DNA Repair and Therapeutic Response in Hepatocellular Carcinoma

MedComm, Volume 7, Issue 9, September 2026.
In hepatocellular carcinoma (HCC) cells exposed to doxorubicin, DUSP12 depletion maintains NAT10 phosphorylation, reducing its acetyltransferase activity, which leads to reduced ac4C RNA acetylation, DNA damage response, and DNA break repair, with consequent tumor sensitization.
Viktor Kalbermatter Boell, Diana Reis Della Corte Guimarães Pacheco, Yuli Thamires Magalhães, Laura Lima Turani, Isabeli Yumi Araújo Osawa, Nicolas Carlos Hoch, Fábio Luís Forti   +6 more
wiley   +1 more source