Results 101 to 110 of about 507,870 (221)

Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation [PDF]

, 2014
Deoxycytidine kinase (dCK) is a critical enzyme for activation of anticancer nucleoside analogs. Its activity is controlled via Ser-74 phosphorylation. Here, we investigated which Ser/Thr phosphatase dephosphorylates Ser-74.
Bontemps, Françoise, Smal, Caroline, Janssens, Veerle, Amsaïlale, Rachid, Van Den Neste, Eric, Beyaert, Maxime   +5 more
core   +1 more source

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells

European Journal of Immunology, Volume 56, Issue 9, September 2026.
(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP‐1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP‐1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation‐induced cytokine secretion in BMMCs via the RAS/ RAF,
Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib   +8 more
wiley   +1 more source

Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography

, 2016
Combined inhibition of ribonucleotide reductase and deoxycytidine kinase (dCK) in multiple cancer cell lines depletes deoxycytidine triphosphate pools leading to DNA replication stress, cell cycle arrest, and apoptosis. Evidence implicating dCK in cancer
Saman Sadeghi (1912072), Hsiang-I Liao (1912075), Zheng Li (26302), Robert Damoiseaux (326975), Ryan Darvish (1912078), Harvey R. Herschman (245626), David A. Nathanson (1629058), Quentin A. Smith (1912087), Dean O. Campbell (1912069), Jason T. Lee (1912084), Anastassia N. Alexandrova (1535254), Chi Hang Lee (1912066), Wayne R. Austin (1912090), Caius G. Radu (611154), Arnon Lavie (307968), Liu Wei (523140), Johannes Czernin (1344825), Julian Nomme (1272369), Michael E. Phelps (1912081), Jennifer M. Murphy (1403350), Amanda L. Armijo (1344828), Jue Wang (58890), Ying Su (206940), Michael E. Jung (404071)   +23 more
core   +1 more source

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David, Ostrowski, M C, Hartman, M, Schaffner, A E, Smith, James L., Hume, D A, Smith, J L, Ostrowski, Michael C., Wei, G, Hofmeister, Joseph K., Hofmeister, J K, Schaffner, Alicia E., Wei, Guo, Hume, David A., Hartman, Matthew, Hartman, Matthew Hartman, Forsthoefel, D   +16 more
core   +1 more source

Understanding the Epigenetic Landscape of Barrett's Esophagus and Esophageal Cancer: A Review of Current Findings, Caveats and Future Directions

Genes, Chromosomes and Cancer, Volume 65, Issue 9, September 2026.
ABSTRACT Esophageal cancer (OC) is currently the eighth most common form of cancer worldwide with a 5‐year survival rate of 10%–20%, with the primary risk factor of esophageal adenocarcinoma (OAC) being the development of Barrett's Esophagus (BO).
Louise Lawless, Trevor Doherty, Carla Surlis, Niamh Gilmartin, Therese M. Murphy   +4 more
wiley   +1 more source

Clonotypic characterization defines B‐cell drivers of clonal expansion and intratumor heterogeneity in IgM monoclonal gammopathies

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) share the same cell of origin but differ in clonal size. Compared with other B‐cell neoplasms, the lymphoplasmacytic clone in WM can be rather small, limiting our understanding of clonal expansion.
David F. Moreno, Ferran Nadeu, Marta Casado‐Peláez, Caterina Mata, Ian Márquez‐López, Marco A. Fernández, Sergi Vaqué, Elena Medina, Helena Llobregat, Marta Garrote, Joan Mañé, Oriol Cardús, Luis Gerardo Rodríguez‐Lobato, Anna de Daniel, María Teresa Cibeira, Theo Gremen Oliveira, Elizaveta Kulaeva, Ester Lozano, Dolors Colomer, Laura Rosiñol, Ruben van Boxtel, Manel Esteller, Carlos Fernández de Larrea   +22 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Deoxycytidine Kinase and Cytosine Nucleoside Deaminase Activities in Synchronized Cultures of Normal Rat Kidney Cells

, 1978
Previous work has suggested that 1-β-D-arabinofurano-sylcytosine 5'-triphosphate is the active metabolite of 1-β-D-arabinofuranosylcytosine. The amount of 1-β-D-arabi-nofuranosylcytosine 5'-triphosphate formed in tissues has been shown to be influenced ...
Mak, Tak W., Wan, Charn Wing
core  

Redesigning Human 2′-Deoxycytidine Kinase Enantioselectivity for L‑Nucleoside Analogues as Reporters in Positron Emission Tomography

, 2015
: Recent advances in nuclear medicine have allowed for positron emission tomography (PET) to track transgenes in cell-based therapies using PET reporter gene/probe pairs.
Pravin Muthu (211340), Hannah X. Chen, Stefan Lutz (1339791), Pravin Muthu, Hannah X. Chen (1339794), Stefan Lutz   +5 more
core   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, Volume 3, Issue 3, September 2026.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source