Deoxycytidine kinase and thymidine kinase activities in rat brain.
Oncology research, 1994 Deoxycytidine (CdR) kinase (E.C. 2.7.1.74) acts as a salvage enzyme in DNA biosynthesis, but little is known about this important nucleoside kinase in the brain. We report that CdR kinase activity in the 100,000 x g cytosolic fraction of normal adult rat brain cortex was 0.89 +/- 0.04 nmol/hr/mg protein which is twice that of the liver enzyme.
R L, Singhal, G, Weber
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A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity. [PDF]
Genes (Basel), 2019 Santos SM +8 more
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Deoxycytidine kinase inhibition: Rewiring tumor nucleotide metabolism for therapeutic gain. [PDF]
Nucleosides Nucleotides Nucleic AcidsClark PM, Thompson CB, Schultz KA.
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Deoxycytidine kinase expression in AML blasts and its relationship to leukemia-free and overall survival: PS101. [PDF]
Porto Biomed J, 2017 Ng L +9 more
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Acquired Resistance to Decitabine Associated with the Deoxycytidine Kinase A180P Mutation: Implications for the Order of Hypomethylating Agents in Myeloid Malignancies Treatment. [PDF]
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Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis. [PDF]
Am J Respir Crit Care Med, 2014 Weng T +13 more
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Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer. [PDF]
Clin Cancer Res, 2014 Kerr M +6 more
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