Results 101 to 110 of about 25,107 (224)
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs [PDF]
, 2014 Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy.
Wang, Xin
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Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets
Food Frontiers, Volume 7, Issue 2, March 2026.After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao +6 more
wiley +1 more source
Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer [PDF]
, 2010 9 páginas, 4 figuras.-- et al.[Background]: Wnt factors control cell differentiation through semi-independent molecular cascades known as the β-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigenetic
Aguilera, Óscar +7 more
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Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress
iNew Medicine, Volume 2, Issue 1, March 2026.ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai +7 more
wiley +1 more source
Biomolecules & BiomedicineProgesterone and adiponectin receptor 3 (PAQR3) is a Golgi-localized seven-transmembrane protein that anchors rapidly accelerated fibrosarcoma kinase (Raf) and suppresses rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase ...
Yan Lv +4 more
doaj +1 more source
The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
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DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site [PDF]
, 2009 20 pages, 7 figures, 1 table.-- PMID: 19467223 [PubMed].-- PMCID: PMC2756644.-- NIHMSID: NIHMS130041.-- Printed version published Sep 15, 2009.Aberrant cytosine methylation in promoter regions leads to gene silencing associated with cancer progression. A
Van Bemmel, Dana M. +4 more
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MedComm, Volume 7, Issue 3, March 2026.Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
Metabolic constraint of human telomere length by nucleotide salvage efficiency
Nature CommunicationsHuman telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz +3 more
doaj +1 more source
Stem Cells International, 2018 The advanced-stage colon cancer spreads from primary tumor site to distant organs where the colon-unassociated stromal population provides a favorable niche for the growth of tumor cells.
Khushboo Agrawal +5 more
doaj +1 more source