Results 21 to 30 of about 202,925 (206)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Lipid peroxidation is a nonparenchymal cell event with reperfusion after prolonged liver ischemia [PDF]

, 1990
A proposed mechanism for irreversible ischemic liver damage has been peroxidation of membrane phospholipids by free radicals. However, the hepatocyte is laden with enzymes which are antioxidants and, therefore, ought to be relatively resistant to ...
Makowka, L, Rao, PN, Starzl, TE, Walsh, TR   +3 more
core   +1 more source

Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]

, 2017
Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver, Blyth, Kevin G., De Fonseka, Duneesha, Edey, Anthony, Lee, Y. C. Gary, Martin, Geoffrey, Maskell, Nick, Piccolo, Francesco, Popowicz, Natalia, Smith, Nicola A., Wong, Donny   +10 more
core   +1 more source

Deoxyribonucleases of Pneumococcus

Journal of Biological Chemistry, 1967
Abstract Two enzymes with deoxyribonuclease activity were isolated from Pneumococcus. One of these, an endonuclease active on both native and denatured deoxyribonucleic acid, produced 5'-phosphate-terminated fragments which, even after extensive degradation, were larger than mononucleotides.
S, Lacks, B, Greenberg
openaire   +2 more sources

Immunothrombosis and Complement Activation Contribute to Disease Severity and Adverse Outcome in COVID-19

Journal of Innate Immunity, 2023
Severe COVID-19 is characterized by systemic inflammation and multiple organ dysfunction syndrome (MODS). Arterial and venous thrombosis are involved in the pathogenesis of MODS and fatality in COVID-19.
Tiphaine Ruggeri, Yasmin De Wit, Noëlia Schärz, Gerard van Mierlo, Anne Angelillo-Scherrer, Justine Brodard, Joerg C. Schefold, Cédric Hirzel, Ilse Jongerius, Sacha Zeerleder   +9 more
doaj   +1 more source

Genetic Studies of Sulfadiazine-resistant and Methionine-requiring \u3cem\u3eNeisseria\u3c/em\u3e Isolated From Clinical Material [PDF]

, 1967
Deoxyribonucleate (DNA) preparations were extracted from Neisseria meningitidis (four isolates from spinal fluid and blood) and N. gonorrhoeae strains, all of which were resistant to sulfadiazine upon primary isolation.
BROWN G. M., CATLIN B. W., CATLIN B. W., CATLIN B. W., CATLIN B. W., CAUTHEN S. E., DAVIS B. D., DAVIS B. D., DEMAIN A. L., DEMEREC M., E., DONALD I. J., DU VIGNEAUD V., W., EICKHOFF T. C., GRABOW W., HARRIS J. S., HATCH F. T., HOTCHKISS R. D., KAPLAN M. M., KATZEN H. M., KOHN H. I., LANDY M., LEDERBERG J., MILLAR J. W., OAKBERG E. F., PATO M. L., REYN A., REYN A., ROWBURY R. J., SICARD A. M., SINGER S., G., SMITH D. A., WILLCOX R. R., WINKLER K. C., WOLF B., WOODS D. D., WOODS D. D.   +35 more
core   +2 more sources

Structure of acid deoxyribonuclease [PDF]

Nucleic Acids Research, 2017
Deoxyribonuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity at the low pH environment of lysosomes where it is typically found in higher eukaryotes. Interestingly, DNase II has also been identified in a few genera of bacteria and is believed to have arisen via horizontal transfer.
Varela-Ramirez, Armando, Abendroth, Jan, Mejia, Adrian A., Phan, Isabelle Q., Lorimer, Donald D., Edwards, Thomas E., Aguilera, Renato J.   +6 more
openaire   +2 more sources

Use of recombinant human deoxyribonuclease in pediatric intensive care unit – a single-center experience

Revista Paulista de Pediatria, 2021
Objective: Dornase alfa (rhDNase) reduces the viscosity of purulent sputum in the lungs. The use in patients with cystic fibrosis (CF) is proven. However, the evidence of its applicability to other conditions is limited.
Daniel Meireles, Sofia Ribeiro Fernandes, Alzira Sarmento, Telma Barbosa, Manuel Ferreira Magalhães, Ana Ramos, Paula Cristina Fernandes   +6 more
doaj   +2 more sources

Chemical and rheological aspects of gel formation in the California Mastitis Test [PDF]

, 2005
The rheological properties of the CMT gel were analysed. Data are presented to demonstrate that the gel is a non-homogenous, visco-elastic, non-Newtonian fluid with rheopectic, and rheodestructive behaviour.
Claycomb, Rod, Liew, Alvin, Mein, Graeme, Walmsley, Michael R.W., Whyte, David   +4 more
core   +2 more sources

Deoxyribonuclease Treatment Improves the Homogeneity of Single-Stranded DNA Preparations

BioTechniques, 1997
The isolation of single-stranded (ss) phagemid DNA using standard protocols often results in impure preparations, which contain undesirable quantities of chromosomal and/or double-stranded (ds) phagemid DNA.
T.K. Aliev, A.A. Panina, V.G. Korobko, S.D. Varfolomeyev   +3 more
doaj   +1 more source