Results 31 to 40 of about 202,925 (206)

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

The Specificity of Pancreatic Deoxyribonuclease [PDF]

European Journal of Biochemistry, 1973
The kinetics of degradation of calf thymus DNA by pancreatic DNAase has been investigated with the main purpose of providing the background for studying the specificity of the enzyme and its use in investigations of nucleotide sequences in DNA. The relationships between the hyperchromic shift or acid solubility and the reciprocal average degree of ...
S. D. Ehrlich, BERTAZZONI, Umberto, G. Bernardi   +2 more
openaire   +3 more sources

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +1 more source

DNA in fresh urine supernatant is not affected by additional centrifugation and is protected against deoxyribonuclease

Molecular and Cellular Probes, 2023
Urinary DNA is widely studied as a non-invasive marker for monitoring of kidneys after transplantation or the progression of urinary tract tumors. The quantity of urinary DNA especially of mitochondrial origin has been reported to mirror kidney damage in
Ľubica Janovičová, Katarína Kmeťová, Ľubomíra Tóthová, Barbora Vlková, Peter Celec   +4 more
doaj   +1 more source

Intrapleural therapy for pleural infection from bronchopleural fistula in an adult with hyper‐IgE syndrome

Respirology Case Reports, 2023
We presented the case of an adult patient with hyper‐IgE syndrome (HIES) who was admitted acutely with a large hydropneumothorax from lung consolidation, a bronchopleural fistula and pleural infection.
Sam Faber, Andrew McLean‐Tooke, Yi Jin Kuok, Y. C. Gary Lee   +3 more
doaj   +1 more source

Purification and characterization of deoxyribonuclease from small intestine of camel Camelus dromedarius

Journal of Genetic Engineering and Biotechnology, 2017
The chromatography of deoxyribonuclease (DNase) from small intestine of camel Camelus dromedarius by DEAE-Sepharose separated three isoforms DNase 1, DNase 2 and DNase 3. The DNase 3 was purified to homogeneity by chromatography on Sephacryl S-200.
Somia S. Abdel-Gany, Mohamed O. El-Badry, Afaf S. Fahmy, Saleh A. Mohamed   +3 more
doaj   +1 more source

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, 2022
Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers.
Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo   +15 more
doaj   +1 more source

Interspecies competition in oral biofilms mediated by Streptococcus gordonii extracellular deoxyribonuclease SsnA

npj Biofilms and Microbiomes, 2022
Extracellular DNA (eDNA) is a key component of many microbial biofilms including dental plaque. However, the roles of extracellular deoxyribonuclease (DNase) enzymes within biofilms are poorly understood.
Nadia Rostami, Robert C. Shields, Hannah J. Serrage, Catherine Lawler, Jane L. Brittan, Sufian Yassin, Halah Ahmed, Achim Treumann, Paul Thompson, Kevin J. Waldron, Angela H. Nobbs, Nicholas S. Jakubovics   +11 more
doaj   +1 more source

Redox metabolism correlates with cellular turnover and clinical phenotype of papillary thyroid carcinoma and colloid goiter

Archives of Medical Science, 2019
Introduction Papillary thyroid carcinoma (PTC) and colloid goiter (CG) represent the most common thyroid malignant and benign diseases, respectively.
Branislav Rovcanin, Kristina Gopcevic, Dusan Kekic, Vladan Zivaljevic, Aleksandar Diklic, Svetislav Tatic, Milan Jovanovic, Bozidar Odalovic, Ivan Paunovic   +8 more
doaj   +1 more source

DEOXYRIBONUCLEASE ACTIVITY IN SEMEN [PDF]

Reproduction, 1968
The methyl green assay method has been used to determine the activity of DNase I and DNase II in ram, bull, human, dog and rabbit seminal plasma. The activity of DNase II was higher except in the ram. The DNase I activity of ram seminal plasma was inhibited by low concentrations of citrate, zinc and cetyltrimethylammonium bromide ; this detergent also ...
openaire   +2 more sources