Results 61 to 70 of about 101,166 (300)
Advanced Science, EarlyView.The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang +7 more
wiley +1 more source
A Molecular Dynamics Simulation Study of the Arg206Cys Variant in DNASE1L3 Enzyme
Biology and Life Sciences Forum, 2022 Genome-wide association studies (GWAS) have identified that one of the autoimmune disease-associated loci, predisposing for the development of Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and Systemic Sclerosis (SSc), is the rs35677470 ...
Manio Skarlatou +3 more
doaj +1 more source
Deoxyribonuclease activities in Lactobacillus delbrueckii
Microbiological Research, 2000 DNase activity was examined in the extracellular and subcellular fractions of six non-transformable strains belonging to Lactobacillus delbrueckii subsp. lactis (L. lactis) and Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) and compared with the activity present in Lactobacillus johnsonii NCK 65, a transformable strain of Lactobacillus. In
Azcárate Peril, M. A. +2 more
openaire +4 more sources
Advanced Science, EarlyView.Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du +7 more
wiley +1 more source
Microorganisms, 2023 Pectobacterium carotovorum subsp. carotovorum (Pcc) is known to produce different types of bacteriocins, active protein substances that inhibit or kill related strains and are known to be induced by several factors. In this paper, we report the discovery,
Huang-Pin Wu +4 more
doaj +1 more source
A Defined Agar Medium for Genetic Transformation of \u3cem\u3eNeisseria meningitidis\u3c/em\u3e [PDF]
, 1962 Catlin, B. Wesley (Marquette University, Milwaukee, Wis.) and Gertrude M. Schloer. A defined agar medium for genetic transformation of Neisseria meningitidis. J. Bacteriol. 83:470–474.
Catlin, B. Wesley, Schloer, Gertrude M.
core +1 more source
Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage
Advanced Science, EarlyView.Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu +18 more
wiley +1 more source
Advanced Science, EarlyView.LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu +11 more
wiley +1 more source
Effect of preparation procedures on intensity of radioautographic labeling is studied [PDF]
, 1967 Effects of tissue preparation and extractive procedures on the intensity of radioautographic labeling are presented in terms of mean grain count per cell in cells labeled with tritiated precursors of proteins or nucleic acids.
Baserga, R., Kisieleski, W. E.
core +1 more source
Mediators of Inflammation, 2012 Introduction. Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase). Thus DNases are potential prerequisites for natural counter regulation of NETs formation. In the present study, we determined
W. Meng +6 more
semanticscholar +1 more source