Results 31 to 40 of about 14,183,395 (235)

Evaluation of all nonsynonymous single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 1, possibly implicated in the blocking of endocytosis-mediated foreign gene transfer. [PDF]

DNA Cell Biol, 2014
Ueki M, Kimura-Kataoka K, Fujihara J, Takeshita H, Iida R, Yasuda T.   +5 more
europepmc   +2 more sources

Cisplatin Nephrotoxicity Is Mediated by Deoxyribonuclease I [PDF]

Journal of the American Society of Nephrology, 2005
Cisplatin is commonly used for chemotherapy in a wide variety of tumors; however, its use is limited by kidney toxicity. Although the exact mechanism of cisplatin-induced nephrotoxicity is not understood, several studies showed that it is associated with DNA fragmentation induced by an unknown endonuclease.
Alexei G. Basnakian, Sudhir V. Shah, Hans Georg Mannherz, Eugene O. Apostolov, Xiaoyan Yin, Markus Napirei   +5 more
openaire   +3 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +1 more source

Composite Hydrogel Modulates Intrinsic Immune-Cascade Neovascularization for Ocular Surface Reconstruction after Corneal Chemical Injury

Gels, 2023
Ocular alkali burns recruit neutrophils and triggers neutrophil extracellular trap (NET)-neovascularization cascade effects that limit ocular surface reconstruction and functional repair.
Jun Zhang, Kun Xi, Guohua Deng, Xi Zou, Peirong Lu   +4 more
doaj   +1 more source

Deoxyribonuclease Treatment Improves the Homogeneity of Single-Stranded DNA Preparations

BioTechniques, 1997
The isolation of single-stranded (ss) phagemid DNA using standard protocols often results in impure preparations, which contain undesirable quantities of chromosomal and/or double-stranded (ds) phagemid DNA.
T.K. Aliev, A.A. Panina, V.G. Korobko, S.D. Varfolomeyev   +3 more
doaj   +1 more source

Self‐Propelled Proteomotors with Active Cell‐Free mtDNA Clearance for Enhanced Therapy of Sepsis‐Associated Acute Lung Injury

Advanced Science, 2023
Acute lung injury (ALI) is a frequent and serious complication of sepsis with limited therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis‐associated ALI can help develop new therapeutic strategies.
Weichang Huang, Lihong Wen, Hao Tian, Jiamiao Jiang, Meihuan Liu, Yicheng Ye, Junbin Gao, Ruotian Zhang, Fei Wang, Huaan Li, Lihan Shen, Fei Peng, Yingfeng Tu   +12 more
doaj   +1 more source

Extraction and purification of bovine pancreatic Deoxyribonuclease I

مجلة مركز بحوث التقنيات الاحيائية, 2010
Samples of bovine pancreatic and calf thymus glands were collected from local slaughterers to extract deoxyribonuclease I enzyme (DNase I) and DNA respectively.
Baidaa S. Hermiz, Ghazi M. Aziz, Abdel kareem A. Alkazaz   +2 more
doaj   +1 more source

New Cytoplasmic Virus-Like Elements (VLEs) in the Yeast Debaryomyces hansenii

Toxins, 2021
Yeasts can have additional genetic information in the form of cytoplasmic linear dsDNA molecules called virus-like elements (VLEs). Some of them encode killer toxins. The aim of this work was to investigate the prevalence of such elements in D.
Xymena Połomska, Cécile Neuvéglise, Joanna Zyzak, Barbara Żarowska, Serge Casaregola, Zbigniew Lazar   +5 more
doaj   +1 more source

Chronic endometritis. Local prooxidant, antioxidant and immunometabolic disorders. An open-label, prospective, randomized study [PDF]

Гинекология
Aim. To determine local features of lipoperoxidation processes, antioxidant defense, state of matrix metalloproteinases in chronic endometritis. Materials and methods.
Oksana A. Gizinger, Yury A. Sorokin, Viktor E. Radzinskiy   +2 more
doaj   +1 more source