Results 41 to 50 of about 170,315 (251)

The inhibition of deoxyribonuclease I by hydroxybiphenyls [PDF]

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract DNA extracted with certain commercial brands of phenol is resistant to hydrolysis by the endonuclease deoxyribonuclease I, while DNA extracted with other brands, or prepared by NaCl extraction, is susceptible to hydrolysis. The agent responsible for inhibition has been shown to be an oxidation product produced in some phenols.
Gottesfeld, J M, Adams, N H, El-Badry, A M, Moses, V, Calvin, M   +4 more
openaire   +3 more sources

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

Genetically Engineered Cellular Nanovesicle as Targeted DNase I Delivery System for the Clearance of Neutrophil Extracellular Traps in Acute Lung Injury

Advanced Science, 2023
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are prevalent critical illnesses with a high mortality rate among patients in intensive care units.
Yang Du, Yining Chen, Fangyuan Li, Zhengwei Mao, Yuan Ding, Weilin Wang   +5 more
doaj   +1 more source

Chemical and rheological aspects of gel formation in the California Mastitis Test [PDF]

, 2005
The rheological properties of the CMT gel were analysed. Data are presented to demonstrate that the gel is a non-homogenous, visco-elastic, non-Newtonian fluid with rheopectic, and rheodestructive behaviour.
Claycomb, Rod, Liew, Alvin, Mein, Graeme, Walmsley, Michael R.W., Whyte, David   +4 more
core   +2 more sources

Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer

Biomedicines, 2021
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA).
Yu-An Chen, Yi-Ru Lai, Hui-Yu Wu, Yen-Ju Lo, Yu-Fang Chang, Chiu-Lien Hung, Chun-Jung Lin, U-Ging Lo, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Yu-Hsin Lin, Chih-Ho Lai   +12 more
doaj   +1 more source

Global identification of prokaryotic glycoproteins based on an Escherichia coli proteome microarray. [PDF]

PLoS ONE, 2012
Glycosylation is one of the most abundant protein posttranslational modifications. Protein glycosylation plays important roles not only in eukaryotes but also in prokaryotes.
Zong-Xiu Wang, Rui-Ping Deng, He-Wei Jiang, Shu-Juan Guo, Huang-Ying Le, Xiao-Dong Zhao, Chien-Sheng Chen, Ji-Bin Zhang, Sheng-Ce Tao   +8 more
doaj   +1 more source

A Fast and Efficient Decellularization Method for Tissue Slices

Bio-Protocol, 2022
The study and use of decellularized extracellular matrix (dECM) in tissue engineering, regenerative medicine, and pathophysiology have become more prevalent in recent years.
Maria Narciso, Anna Ulldemolins, Constança Júnior, Jorge Otero, Daniel Navajas, Ramon Farré, Núria Gavara, Isaac Almendros   +7 more
doaj   +1 more source

Cisplatin Nephrotoxicity Is Mediated by Deoxyribonuclease I [PDF]

Journal of the American Society of Nephrology, 2005
Cisplatin is commonly used for chemotherapy in a wide variety of tumors; however, its use is limited by kidney toxicity. Although the exact mechanism of cisplatin-induced nephrotoxicity is not understood, several studies showed that it is associated with DNA fragmentation induced by an unknown endonuclease.
Alexei G, Basnakian, Eugene O, Apostolov, Xiaoyan, Yin, Markus, Napirei, Hans Georg, Mannherz, Sudhir V, Shah   +5 more
openaire   +2 more sources

AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

Molecular Oncology, 2020
Liver metastasis is the main cause of colorectal cancer (CRC)‐related death. Neutrophil extracellular traps (NETs) play important roles in CRC progression.
Yujia Xia, Jiayi He, Hongji Zhang, Han Wang, George Tetz, Casey A. Maguire, Yu Wang, Amblessed Onuma, Dmitry Genkin, Victor Tetz, Alexey Stepanov, Stanislav Terekhov, Valeria Ukrainskaya, Hai Huang, Allan Tsung   +14 more
doaj   +1 more source

Early DNase-I therapy delays secondary brain damage after traumatic brain injury in adult mice

Scientific Reports, 2023
Traumatic brain injury (TBI) causes the release of danger-associated molecular patterns (DAMP) from damaged or dead cells, which contribute to secondary brain damage after TBI.
Tobias J. Krämer, Florian Pickart, Bruno Pöttker, Christina Gölz, Axel Neulen, Tobias Pantel, Hermann Goetz, Katharina Ritter, Michael K. E. Schäfer, Serge C. Thal   +9 more
doaj   +1 more source