Results 1 to 10 of about 1,745 (200)

Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly [PDF]

Acta Pharmaceutica Sinica B, 2023
Depsides and depsidones have attracted attention for biosynthetic studies due to their broad biological activities and structural diversity. Previous structure‒activity relationships indicated that triple halogenated depsidones display the best anti ...
Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju   +4 more
doaj   +4 more sources

Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp. [PDF]

Marine Drugs
Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation.
Zequan Huang, Dong Liu, Shang Chen, Jinwei Ren, Chenghai Gao, Zhiyong Li, Aili Fan, Wenhan Lin   +7 more
doaj   +4 more sources

Bioproduction of Depsidones for Pharmaceutical Purposes [PDF]

, 2011
الأشنات هي تكافلات حميمة وطويلة الأجل محددة من الطحالب الضوئية أو البكتيريا الزرقاء والفطريات غيرية التغذية التي انضمت لتشكيل كيان بيولوجي جديد مختلف عن مكوناته الفردية (جالون وكارديش، 1995). ينتج الكلوروليكين بشكل أساسي مواد فينولية فريدة من نوعها، ديبيد، ديبسيدون وبعض ثنائي بنزوفيوران، مثل أحماض اليوزنيك (Huneck & Yoshimura، 1996)، التي لا تنتجها ...
Carlos Vicente, María Estrella Legaz, Roberto de Armas   +2 more
core   +5 more sources

Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities [PDF]

PeerJ, 2023
Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens.
Maan T. Khayat, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Gamal A. Mohamed, Sabrin RM Ibrahim   +5 more
doaj   +3 more sources

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells [PDF]

Molecules, 2021
The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens.
Katarzyna Papierska, Violetta Krajka-Kuźniak, Jarosław Paluszczak, Robert Kleszcz, Marcin Skalski, Elżbieta Studzińska-Sroka, Wanda Baer-Dubowska   +6 more
doaj   +2 more sources

Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant [PDF]

Molecules, 2018
A new depsidone derivative (1), aspergillusidone G, was isolated from a marine fungus Aspergillus unguis, together with eight known depsidones (2‒9) and a cyclic peptide (10): agonodepside A (2), nornidulin (3), nidulin (4), aspergillusidone F (5 ...
Wen-Cong Yang, Hai-Yan Bao, Ya-Yue Liu, Ying-Ying Nie, Jing-Ming Yang, Peng-Zhi Hong, Yi Zhang   +6 more
doaj   +2 more sources

Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored [PDF]

Biomolecules, 2022
Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones
Levy Tenório Sousa Domingos, Raquel dos Santos Martins, Leonardo Melo de Lima, Angela Michelato Ghizelini, Antonio Ferreira-Pereira, Fernando Cotinguiba   +5 more
doaj   +2 more sources

In Vitro and In Vivo Anti-Phytopathogenic Fungal Activity of a Culture Extract of the Marine-Derived Fungus, Aspergillus unguis KUFA 0098, and Its Major Depsidone Constituents [PDF]

Marine Drugs
The crude ethyl acetate extract of the culture of a marine sponge-associated fungus, Aspergillus unguis KUFA 0098, was tested for its capacity to inhibit the growth of ten phytopathogenic fungi, viz.
Decha Kumla, Diana I. C. Pinho, Emília Sousa, Tida Dethoup, Luis Gales, Sharad Mistry, Artur M. S. Silva, Anake Kijjoa   +7 more
doaj   +2 more sources

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications [PDF]

Molecules
Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms.
Sayed H. A. Mohamed, Yehia A.-G. Mahmoud, Mohamed Y. Bediway, Sobhy E. Elsilk, Mohammed Yosri, Kamel Metwally, Nader E. Abo-Dya, Galal Yahya, Mervt Almostafa, Atef A. El-Hela   +9 more
doaj   +2 more sources

Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists [PDF]

Molecules, 2023
The discovery of natural drug metabolites is a leading contributor to fulfilling the sustainable development goal of finding solutions to global health challenges.
Gamal A. Mohamed, Abdelsattar M. Omar, Dana F. AlKharboush, Mona A. Fallatah, Ikhlas A. Sindi, Dina S. El-Agamy, Sabrin R. M. Ibrahim   +6 more
doaj   +2 more sources