Results 51 to 60 of about 9,955 (253)
Marine Drugs, 2013 During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans.
Louise Kjaerulff +6 more
doaj +1 more source
Production of the Monamycins, Novel Depsipeptide Antibiotics [PDF]
Applied Microbiology, 1970 Methods are described for the production of the monamycins by Streptomyces jamaicensis in shake flasks and jar fermentors. The effects on the fermentation of variations in p H, temperature, medium composition, volume of inoculum, and strain of the ...
M J, Hall, C H, Hassall
openaire +2 more sources
Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
doaj +1 more source
Bouillonamide: A Mixed Polyketide–Peptide Cytotoxin from the Marine Cyanobacterium Moorea bouillonii
Marine Drugs, 2013 The tropical marine cyanobacterium, Moorea bouillonii, has gained recent attention as a rich source of bioactive natural products. Continued chemical investigation of this cyanobacterium, collected from New Britain, Papua New Guinea, yielded a novel ...
Lik Tong Tan +2 more
doaj +1 more source
Depsipeptide inhibits removal of incorporated 5-aza-CdR from DNA.
, 2013 (A) H719 cells were incubated with [3H]-5-aza-CdR for 48 hrs, with presence or absence of depsipeptide at 0.1 µM for the first 6 hrs (depsipeptide+[3H]-5-aza-CdR) or last 6 hrs ([3H]-5-aza-CdR+depsipeptide) and then washed with cold PBS.
Donglai Wang (49052) +15 more
core +1 more source
Oncology Report, 2016 Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects.
K. Okada +5 more
semanticscholar +1 more source
Combined Application of Orthogonal Sortases and Depsipeptide Substrates for Dual Protein Labeling [PDF]
, 2022 Staphylococcus aureus sortase A is a transpeptidase that has been extensively exploited for site-specific modification of proteins and was originally used to attach a labeling reagent containing an LPXTG recognition sequence to a protein or peptide with ...
Michael E. Webb (4419319) +4 more
core +2 more sources
Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives
Marine Drugs, 2022 Some derivatives of dolastatin 16, a depsipeptide natural product first obtained from the sea hare Dolabella auricularia, were synthesized through second-generation synthesis of two unusual amino acids, dolaphenvaline and dolamethylleuine.
Loida O. Casalme +8 more
doaj +1 more source
The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage
, 2012 Histone deacetylase (HDAC) inhibitors have been proven to be effective therapeutic agents to kill cancer cells through inhibiting HDAC activity or altering the structure of chromatin.
Bo Tu +13 more
core +1 more source
Cancer Science, 2017 Histone deacetylase (HDAC)/phosphatidylinositol 3‐kinase (PI3K) dual inhibition is a promising strategy for the treatment of intractable cancers because of the advantages of overcoming potential resistance and showing synergistic effects.
K. Saijo +5 more
semanticscholar +1 more source