Results 11 to 20 of about 11,747 (273)

Pathogenic Roles of S100A8 and S100A9 Proteins in Acute Myeloid and Lymphoid Leukemia: Clinical and Therapeutic Impacts

Molecules, 2021
Deregulations of the expression of the S100A8 and S100A9 genes and/or proteins, as well as changes in their plasma levels or their levels of secretion in the bone marrow microenvironment, are frequently observed in acute myeloblastic leukemias (AML) and ...
Julie Mondet, Simon Chevalier, Pascal Mossuz   +2 more
doaj   +1 more source

Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39): A Gene Expression Study

Turkish Journal of Hematology, 2015
INTRODUCTION: We aimed to understand the molecular pathways affected by bortezomib and arsenic trioxide treatment on myelomonocytoid cell line P39.
Hakan Savlı, Sara Galimberti, Deniz Sünnetçi, Martina Canesastraro, Giuseppe Palumbo, Balint Nagy, Francesco Di Raimondo, Mario Petrini   +7 more
doaj   +3 more sources

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia. [PDF]

PLoS ONE, 2018
Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been ...
Celine Saint-Laurent, Stephanie Garcia, Vincent Sarrazy, Karine Dumas, Florence Authier, Sophie Sore, Albert Tran, Philippe Gual, Isabelle Gennero, Jean-Pierre Salles, Elvire Gouze   +10 more
doaj   +1 more source

Integrative modelling of the influence of MAPK network on cancer cell fate decision.

PLoS Computational Biology, 2013
The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected signalling pathways involved in diverse cellular processes, such as cell cycle, survival, apoptosis and differentiation.
Luca Grieco, Laurence Calzone, Isabelle Bernard-Pierrot, François Radvanyi, Brigitte Kahn-Perlès, Denis Thieffry   +5 more
doaj   +1 more source

Targeting Aberrant Histone Posttranscription Modification Machinery in Esophageal Squamous Cell Carcinoma: Current Findings and Challenges

Research, 2022
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy, but the survival rates of patients with ESCC have not improved as yet largely because the available targeted therapies are limited.
Gang Ma, Tongyang Gong, Zhihua Liu
doaj   +1 more source

Selection of endogenous control and identification of significant microRNA deregulations in cervical cancer

Frontiers in Oncology, 2023
IntroductionCervical cancer causes approximately 350,000 deaths each year. The availability of sensitive and specific diagnostic tests to detect cervical cancer in its early stages is essential to improve survival rates.MethodsIn this study, we compared ...
T. Stverakova, I. Baranova, I. Baranova, P. Mikyskova, B. Gajdosova, H. Vosmikova, J. Laco, V. Palicka, H. Parova   +8 more
doaj   +1 more source

New clinical trial designs in the era of precision medicine

Molecular Oncology, 2019
Cancer treatment has made significant strides towards the promise of personalized medicine. Recent scientific advances have shown that there are numerous genetic deregulations that are common in multiple cancer types, raising the possibility of ...
Elena Garralda, Rodrigo Dienstmann, Alejandro Piris‐Giménez, Irene Braña, Jordi Rodon, Josep Tabernero   +5 more
doaj   +1 more source

E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis

Toxics, 2020
E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a “healthy method” of tobacco consumption.
Anas A. Ashour, Hashim Alhussain, Umar Bin Rashid, Labiba Abughazzah, Ishita Gupta, Ahmed Malki, Semir Vranic, Ala-Eddin Al Moustafa   +7 more
doaj   +1 more source

Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. [PDF]

, 2013
BackgroundThe aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression.
Boutros, Paul C, Chamankhah, Mahmood, Eftekharpour, Eftekhar, Fehlings, Michael G, Karimi-Abdolrezaee, Soheila, San-Marina, Serban   +5 more
core   +3 more sources

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

iScience, 2023
Summary: MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS).
Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J. Rodriguez, Durgadevi Alagappan, Su Min Lim, Yik-Lam Cho, Yuji Shimizu, Alfred Xuyang Sun, Sheue-Houy Tyan, Edward Koo, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Katsutomo Okamura, Shuo-Chien Ling   +19 more
doaj   +1 more source