Results 61 to 70 of about 253,815 (263)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An Efficient Class of Traub–Steffensen-Type Methods for Computing Multiple Zeros

Axioms, 2019
Numerous higher-order methods with derivative evaluations are accessible in the literature for computing multiple zeros. However, higher-order methods without derivatives are very rare for multiple zeros.
Deepak Kumar, Janak Raj Sharma, Clemente Cesarano   +2 more
doaj   +1 more source

Inertial-Based Derivative-Free Method for System of Monotone Nonlinear Equations and Application

IEEE Access, 2020
Iterative methods for solving nonlinear problems are of great importance due to their appearance in various areas of applications. In this paper, based on the inertial effect, we propose two projection derivative-free iterative methods for solving system
Aliyu Muhammed Awwal, Poom Kumam, Lin Wang, Shuang Huang, Wiyada Kumam   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

On Generalized Composite Fractional Derivative

Walailak Journal of Science and Technology, 2014
In the present paper, we define a generalized composite fractional derivative and obtain results, which include the image of power function, Laplace transform and composition of Riemann-Liouville fractional integral with the generalized composite ...
Mridula GARG, Pratibha MANOHAR, Lata CHANCHALANI, Subhash ALHA   +3 more
doaj   +1 more source

On Derivative-Free Optimisation Methods

, 2023
As part of the field of mathematical optimisation, derivative-free optimisation is the study of optimisation methods that are not granted full access to the derivative of the objective function. In this master's thesis, three derivative-free optimisation methods known from the literature that do not use the derivatives have been studied, namely the ...
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Derivative-free HS-DY-type method for solving nonlinear equations and image restoration

Heliyon, 2020
A derivative-free conjugate gradient algorithm for solving nonlinear equations and image restoration is proposed. The conjugate gradient (CG) parameter of the proposed algorithm is a convex combination of Hestenes-Stiefel (HS) and Dai-Yuan (DY) type CG ...
Auwal Bala Abubakar, Poom Kumam, Abdulkarim Hassan Ibrahim, Jewaidu Rilwan   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source