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Suppression of Experimental Autoimmune Encephalomyelitis by Dermatan Sulfate
Cellular Immunology, 1999The effect of dermatan sulfate (DS) on the treatment of Lewis rats with experimental autoimmune encephalomyelitis (EAE) was examined. DS, a sulfated glycosaminoglycan, has been reported to exhibit anticoagulant and fibrinolytic activities. DS treatment (50 mg/kg/day) facilitates recovery from the clinical manifestations of EAE.
Yuji Inaba +6 more
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Chondroitin/dermatan sulfate in the central nervous system
Current Opinion in Structural Biology, 2007In the central nervous system (CNS) chondroitin sulfate proteoglycans, as one of the major barrier-forming molecules, influence cell migration patterns and axon pathfinding. By contrast, chondroitin sulfate side chains often form hybrid chains with dermatan sulfate and serve as a neural stem cell marker and neurogenic/neuritogenic molecules involved in
Tadahisa Mikami, Kazuyuki Sugahara
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Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria
Glycoconjugate Journal, 2016Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and oligosaccharides belong to the formylglycine-dependent family of sulfatases and have been widely found in various mammalian and bacterial organisms.
Shumin Wang +2 more
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The dermatan sulfate proteoglycans of the adult human meniscus
Journal of Orthopaedic Research, 1992AbstractThe dermatan sulfate proteoglycans decorin and biglycan were extracted from pooled adult human menisci with 4 M guanidinium chloride and purified by successive cesium chloride density gradient centrifugation, ion exchange chromatography, and gel filtration.
Robert J. White, Peter J. Roughley
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β-N-Acetylhexosaminidase Active on Dermatan Sulfate
Enzyme, 1975The dodecasaccharide obtained by treating dermatan sulfate with testicular hyaluronidase, chondroitinase AC, and beta-glucuronidase was incubated with diluted, normal human serum at pH 4.5 or 7.0 followed by chondro-4-sulfatase at pH 7.0. Analyses of the reaction products indicate release of hexosamine but not further degradation of the substrate.
Singh J, Di Ferrante N, Coppa Gv
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Pharmacokinetics of Heparin and of Dermatan Sulfate: Clinical Implications
1992The pharmacokinetic data concerning heparin and dermatan sulfate are usually based upon the disappearance of the biological activities generated after parenteral administration, and not upon the direct determination of their chemical concentrations. At least for heparin, these biological activities are mainly related to the polysaccharide chain length ...
Pierre Sie +4 more
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Dermatan sulfate: Recent structural and activity data
Carbohydrate Polymers, 2010Abstract DS is a natural, complex polysaccharide which plays an important role in cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections. Although its clinical use is limited, DS performs interesting biological activities, which should help in the development of DS-based therapeutics, such as drugs for parasitic ...
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Dermatan Sulfate in Pharmaceutical Heparins
Thrombosis and Haemostasis, 1987Arthur S. Perlin +3 more
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Structure of Heparan Sulfate and Dermatan Sulfate
Annals of the New York Academy of Sciences, 1989openaire +3 more sources
Vascular Dermatan Sulfate and Heparin Cofactor II
2010Heparin cofactor II (HCII) is a plasma protease inhibitor of the serpin family that inactivates thrombin by forming a covalent 1:1 complex. The rate of complex formation increases more than 1000-fold in the presence of dermatan sulfate (DS). Endothelial injury allows circulating HCII to enter the vessel wall, where it binds to DS and presumably becomes
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