Results 1 to 10 of about 1,740 (174)

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL [PDF]

Scientific Reports, 2023
Snakebite envenoming is a global public health issue that causes significant morbidity and mortality, particularly in low-income regions of the world.
William Laprade, Keirah E. Bartlett, Charlotte R. Christensen, Taline D. Kazandjian, Rohit N. Patel, Edouard Crittenden, Charlotte A. Dawson, Marjan Mansourvar, Darian S. Wolff, Thomas Fryer, Andreas H. Laustsen, Nicholas R. Casewell, José María Gutiérrez, Steven R. Hall, Timothy P. Jenkins   +14 more
doaj   +13 more sources

Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. [PDF]

PLoS ONE, 2016
Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Mara A Corrêa, Cinthya K Okamoto, Rute M Gonçalves-de-Andrade, Carmen W van den Berg, Denise V Tambourgi   +4 more
doaj   +24 more sources

Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models, severe local envenoming, defined by morbidity-causing local tissue necrosis, remains poorly ...
Jaffer Alsolaiss, Gail Leeming, Rachael Da Silva, Nessrin Alomran, Nicholas R. Casewell, Abdulrazaq G. Habib, Robert A. Harrison, Cassandra M. Modahl   +7 more
doaj   +9 more sources

Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: Although loxoscelism (bites by brown spiders of the genus Loxosceles) frequently results in dermonecrosis, no previous clinical reports have provided detailed temporal photodocumentation of the evolution of dermonecrotic lesions in a case ...
Carla Fernanda Borrasca-Fernandes, Camila Carbone Prado, Eduardo Mello De Capitani, Stephen Hyslop, Fábio Bucaretchi   +4 more
doaj   +9 more sources

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms [PDF]

Nature Communications, 2023
Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven R. Hall, Sean A. Rasmussen, Edouard Crittenden, Charlotte A. Dawson, Keirah E. Bartlett, Adam P. Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R. Casewell   +9 more
doaj   +8 more sources

Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper [PDF]

Mediators of Inflammation, 2002
Envenomations by the snake Bothrops asper are characterized by prominent local tissue damage (i.e. myonecrosis), blistering, hemorrhage and edema. Various phospholipases A2 and metalloproteinases that induce local pathological alterations have been ...
Alexandra Rucavado, Teresa Escalante, Catarina F. P. Teixeira, Cristina María Fernándes, Cecilia Díaz, José María Gutiérrez   +5 more
doaj   +6 more sources

Snake Venom Metalloproteinases from Puff Adder and Saw-Scaled Viper Venoms Cause Cytotoxic Effects in Human Keratinocytes [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via dermonecrosis around ...
Keirah E. Bartlett, Adam Westhorpe, Mark C. Wilkinson, Nicholas R. Casewell   +3 more
doaj   +6 more sources

Local Cytotoxic Effects in Cobra Envenoming: A Pilot Study [PDF]

Toxins, 2022
The cobra (genus Naja (N.)) is one of the most common venomous snakes. Due to its frequency and deadly complications of muscle paralysis, local necrosis, and chronic musculoskeletal disability, it should not be ignored.
Jing-Hua Lin, Wang-Chou Sung, Han-Wei Mu, Dong-Zong Hung   +3 more
doaj   +2 more sources

Protection against Staphylococcus aureus Colonization and Infection by B- and T-Cell-Mediated Mechanisms [PDF]

mBio, 2018
Staphylococcus aureus is a major cause of morbidity and mortality worldwide. S. aureus colonizes 20 to 80% of humans at any one time and causes a variety of illnesses. Strains that are resistant to common antibiotics further complicate management.
Fan Zhang, Olivia Ledue, Maria Jun, Cibelly Goulart, Richard Malley, Ying-Jie Lu   +5 more
doaj   +2 more sources

Brown Spider Venom Phospholipases D: From Potent Molecules Involved in Pathogenesis of Brown Spider Bites to Molecular Tools for Studying Ectosomes, Ectocytosis, and Its Applications [PDF]

Toxins
Accidents caused by Loxosceles spiders, commonly known as brown spiders, are frequent in warm and temperate regions worldwide, with a higher prevalence in South America and the southern United States.
Ana Carolina Martins Wille, Mariana Izabele Machado, Samira Hajjar Souza, Hanna Câmara da Justa, Maria Eduarda de Fraga-Ferreira, Eloise de Souza Mello, Luiza Helena Gremski, Silvio Sanches Veiga   +7 more
doaj   +2 more sources