Results 31 to 40 of about 1,740 (174)

Tetracycline Protects against Dermonecrosis Induced by Loxosceles Spider Venom [PDF]

Journal of Investigative Dermatology, 2007
Envenomation by spiders belonging to the Loxosceles genus (brown spider) often results in local dermonecrotic lesions. We have previously shown that Loxosceles sphingomyelinase D (SMase D), the venom component responsible for all the pathological effects, induced the expression of matrix metalloproteinases (MMPs) in rabbits and in human keratinocytic ...
Danielle Paixão-Cavalcante, Carmen W. van den Berg, Rute M. Gonçalves-de-Andrade, Matheus de Freitas Fernandes‐Pedrosa, Cinthya Kimori Okamoto, Denise V. Tambourgi   +5 more
openalex   +3 more sources

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice

Toxicon, 2016
The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja nigricollis was investigated in a mouse model. Intradermal injection of venom induced a macroscopic necrotic lesion. Histological examination revealed early edema of the dermis, followed by blistering, loss of skin appendages and reduction in cellularity. By 24 h,
Mario Rivel, Daniela Solano, María Herrera, Mariángela Vargas, Mauren Villalta, Álvaro Segura, Ana Silvia Arias, Guillermo León, José Marı́a Gutiérrez   +8 more
openalex   +6 more sources

A single amino acid substitution in Fibronectin Binding protein A (FnBPA) governs Staphylococcus aureus virulence via host transglutaminase-mediated fibrin crosslinking. [PDF]

PLoS Pathog
Staphylococcus aureus is an opportunistic pathogen that can cause different types of infections, ranging from skin lesions to life threatening diseases.
Motta C, Turley M, Barbieri G, Famà A, Coppolino F, Bellan Menegussi E, Geoghegan JA, Beninati C, Pellegrini A, Pietrocola G.   +9 more
europepmc   +3 more sources

Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination. [PDF]

Nat Commun
Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S.
Tomaszewski KL, Blanchard M, Olaniyi R, Brenton HR, Hayes S, Fatma F, Amarasinghe GK, Cho BK, Goo YA, DeDent AC, Fritz SA, Wardenburg JB.   +11 more
europepmc   +3 more sources

Spider Bite Dermonecrosis: A Review of Loxoscelism

Journal of Surgery Research and Practice
Loxoscelism is the clinical condition caused by the bite of spiders belonging to the genus Loxosceles and is the only verified arachnological cause of dermonecrosis worldwide. More than 150 different species of this spider genus have been described, being Loxosceles laeta the only recognized cause of Loxoscelism in Chile.
Pedro Vidal GH
openalex   +2 more sources

Anti-Alpha-Toxin Monoclonal Antibody and Antibiotic Combination Therapy Improves Disease Outcome and Accelerates Healing in a Staphylococcus aureus Dermonecrosis Model [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S.
Jamese J. Hilliard, Vivekananda Datta, Christine Tkaczyk, Melissa Hamilton, Agnieszka Sadowska, Omari Jones-Nelson, Terrence O’Day, Jason Weiss, Szabolcs Szarka, Vien Nguyen, László Prókai, JoAnn Suzich, C. Kendall Stover, Bret R. Sellman   +13 more
openalex   +3 more sources

Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy [PDF]

Toxins, 2022
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to about 40 to 60% of the cobra venom proteome, play a significant role in cobra
Bhargab Kalita, Yuri N. Utkin, Ashis K. Mukherjee   +2 more
doaj   +2 more sources

A biofilm-targeting lipo-peptoid to treat Pseudomonas aeruginosa and Staphylococcus aureus co-infections [PDF]

Biofilm
Antibiotic-resistant bacterial infections are a significant clinical challenge, especially when involving multiple species. Antimicrobial peptides and their synthetic analogues, peptoids, which target bacterial cell membranes as well as intracellular ...
Samuel J.T. Wardell, Deborah B.Y. Yung, Josefine E. Nielsen, Rajesh Lamichhane, Kristian Sørensen, Natalia Molchanova, Claudine Herlan, Jennifer S. Lin, Stefan Bräse, Lyn M. Wise, Annelise E. Barron, Daniel Pletzer   +11 more
doaj   +2 more sources

Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation [PDF]

Toxins, 2022
Bites of Loxosceles spiders can lead to a set of clinical manifestations called loxoscelism, and are considered a public health problem in many regions. The signs and symptoms of loxoscelism are divided into cutaneous and systemic forms.
Luiza Helena Gremski, Hanna Câmara da Justa, Nayanne Louise Costacurta Polli, Pedro Henrique de Caires Schluga, João Lucas Theodoro, Ana Carolina Martins Wille, Andrea Senff-Ribeiro, Silvio Sanches Veiga   +7 more
doaj   +2 more sources

Editorial: venom collection. [PDF]

Sci Rep
Venoms are naturally available biological resources with a huge potential to explore numerous pharmacologically valuable compounds to diagnose and treat human diseases. Therefore, researching venoms is not only beneficial to develop better diagnostic and
Vaiyapuri S, Falabella P.
europepmc   +3 more sources