Results 41 to 50 of about 1,740 (174)
Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency [PDF]
Clinical and Vaccine Immunology, 2012 ABSTRACTStaphylococcus aureusalpha toxin (AT) is an important virulence determinant and may be a valid target for immunoprophylaxis against staphylococcal disease. Here we report the identification of potent inhibitory anti-AT monoclonal antibodies (MAbs) derived using B-cell hybridoma technology from VelocImmune mice engineered to produce IgG with a ...
Christine Tkaczyk +11 more
openalex +3 more sources
Immunology, 1975 Mice were protected against the dermonecrotic effects of Staphylococcus aureus by previous infection with either coagulase-positive or coagulase-negative strains or by immunization with alpha-toxin. Passive protection was conferred by serum from previously infected mice or by alpha-antitoxin.
C S Easmon, A. A. Glynn
openalex +3 more sources
Angewandte Chemie, Volume 134, Issue 24, June 13, 2022., 2022 A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.
Korbin H. J. West +8 more
wiley +2 more sources
Microorganisms, 2021 USA300 is a predominant and highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain that is a leading cause of skin and soft tissue infections.
Jack Zhang +8 more
doaj +1 more source
Frontiers in Veterinary Science, 2022 Loxosceles spp. (brown spiders) bites are responsible for the development of a syndrome consisting mainly of dermonecrotic lesions, and also systemic effects.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
Clinical Effects of the Immunization Protocol Using Loxosceles Venom in Naïve Horses
Toxins, 2022 Bites of brown spiders (Loxosceles spp.) are responsible for dermonecrotic lesions and potentially systemic envenoming that can lead to death. The only effective therapy is the use of the antivenom, usually produced in horses.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
An oral caspase inhibitor as monotherapy or with antibiotics eradicates MRSA skin infections in mice
Drug Development Research, Volume 84, Issue 8, Page 1567-1571, December 2023., 2023 Abstract Staphylococcus aureus is the leading cause of skin and soft tissue infections. With the emergence of antibiotic‐resistant bacteria, there is an unmet clinical need to develop immune‐based therapies to treat skin infections. Previously, we have shown pan‐caspase inhibition as a potential host‐directed immunotherapy against community‐acquired ...
Emily Cahill +6 more
wiley +1 more source
South African Medical Journal, 2022 Wound infections following cytotoxic snakebites are common. Bites from Naja nigricincta nigricincta (an African spitting cobra) usually present as severe dermonecrosis spreading within the subdermal fascia layer.
EL Saaiman, PJ (Christo) Buys
doaj +1 more source
The Health Status of Horses Used for at Least Six Complete Cycles of Loxoscelic Antivenom Production
Toxins, 2023 Antivenom production against Loxosceles venom relies on horses being immunized and bled for plasma harvest. One horse can partake in several cycles of antivenom production, which will require years of constant venom and adjuvant inoculation and bleeding.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
Targeting the Pseudomonas aeruginosa Virulence Factor Phospholipase C With Engineered Liposomes
Frontiers in Microbiology, 2022 Engineered liposomes composed of the naturally occurring lipids sphingomyelin (Sm) and cholesterol (Ch) have been demonstrated to efficiently neutralize toxins secreted by Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus.
Heidi Wolfmeier +9 more
doaj +1 more source